01), while for young there was no statistical significant difference with T(a) 28 degrees C; (4) the shin of the elderly was seven and nine times less sensitive to warmth when compared to those of the cheek at T(a) 28 and 22 degrees C, respectively; and (5) warm thresholds were 3-4 degrees C greater at T(a) 22 degrees C than at 28 degrees C, only check details for the elderly males’ shin and foot (p < 0.05), while for young the difference between T(a) 22 and 28 degrees C was not statistically significant. The results indicate that age-related differences in cutaneous warm perception appear to be non-uniform over the body and significant on extremities; there is
a greater bluntness of warm sensitivity in the cool environment for elderly males. (C) 2010 Elsevier Ltd. All rights reserved.”
“5-Hydroxytryptamine (5-HT or serotonin) click here is an important neurotransmitter for a number of brain functions and widely distributed throughout the brain. Physiological and pharmacological relationship between 5-HT1A receptors and serotonin transporter (5-HTT) in the regulation of 5-HT neurotransmission has now been documented. A relationship between 5-HT1A receptors and 5-HTT is also suggested by the pathophysiology of depression and the mechanism of action of antidepressants. We have scanned 42 healthy adults with both [11C] WAY-100635 and [11C] DASB to investigate the anatomical co-distribution of multiple serotonergic
markers. We hypothesized that lower 5-HTT densities in the dorsal raphe nucleus (DRN) and limbic regions will be accompanied by lower
5-HT1A receptor density in the same regions, contributing to the 5-HT1A receptor desensitization. In addition, variations in DRN 5-HT1A receptor density can theoretically influence the density and/or function of other serotonin receptor subtypes and the 5-HTT consequent to changes in serotonergic tone. In a comparatively large sample of volunteers, we have shown that the relationship Non-specific serine/threonine protein kinase between 5-HT1A and 5-HTT PET indices was complex. We were unable to demonstrate robust, intra-regional relationships between 5-HT1A and 5-HTT densities. Inter-regionally, DRN 5-HT1A receptors were related to cortical (temporal and frontal regions) and paralimbic (insula), but not limbic 5-HTT. This latter finding may reflect differences in 5-HT tone between individuals, and highlights probable substrates sensitive to variations in DRN 5-HT function. Neuropsychopharmacology (2011) 36, 2258-2265; doi: 10.1038/npp.2011.113; published online 13 July 2011″
“When animals consume less food, they must reduce their body temperature to maximize growth. However, high temperatures enhance locomotion and other performances that determine survival and reproduction. Therefore, thermoregulatory behaviors during different metabolic states reveal the relative importance of conserving energy and sustaining performance.
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