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“Auditory evoked potentials (AEPs) provide an objective measure of auditory cortical function, but AEPs from cochlear implant (CI) users are contaminated by an electrical artifact. Here, we investigated the effects of electrical artifact attenuation on AEP quality. The ability of independent component
analysis (ICA) in attenuating the CI artifact while preserving the AEPs was evaluated. AEPs recovered from CI users were systematically correlated click here with age, demonstrating that individual differences were well preserved. CI users with high-quality AEPs were characterized by a significantly shorter duration of deafness. Finally, a simulation study revealed very high spatial correlations between original and recovered normal hearing AEPs (r>.95) that were previously contaminated with CI artifacts. The results confirm that after ICA, good quality AEPs can be recovered, facilitating the objective, noninvasive INCB28060 chemical structure study of auditory cortex function in CI users.”
“The anterior cingulate cortex (ACC) is central to evaluating performance outcomes and has been linked to individual differences in affective responses to feedback. We used electrophysiological source localization to examine the feedback-related negativity (FRN) and related ACC activity during a gambling
task in relation to punishment and reward sensitivity among 16- to 17-year-old adolescents (n = 20) and 18- to 29-year-old adults (n = 30). The FRN was larger for monetary loss compared to win feedback and larger for high relative to low monetary value feedback, with no age
differences in the FRN for win or loss feedback. Self-reported sensitivity to punishment accounted for unique variance (over sex and sensitivity to reward) in FRNs, with higher scores relating Gemcitabine to larger FRNs and increased rostral ACC activity. These results support the ACC role in experiencing negative performance feedback, especially for individuals highly sensitive to punishment.”
“We used an intermittent stimulus presentation to investigate event-related potential (ERP) components associated with perceptual reversals during binocular rivalry. The combination of spatiotemporal ERP analysis with source imaging and statistical parametric mapping of the concomitant source differences yielded differences in three time windows: reversals showed increased activity in early visual (similar to 120 ms) and in inferior frontal and anterior temporal areas (similar to 400-600 ms) and decreased activity in the ventral stream (similar to 250-350 ms). The combination of source imaging and statistical parametric mapping suggests that these differences were due to differences in generator strength and not generator configuration, unlike the initiation of reversals in right inferior parietal areas.
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