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“Background/Aims: Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans. Methods: Study participants (n = 848; 21 families) were genotyped for the three polymorphisms
by TaqMan assay. Association between the genotypic and phenotypic data was performed by measured genotype approach click here as implemented in the variance component analytical tools. Results: The Arg148Gly variant was found to be monomorphic in our dataset. Of the phenotypes examined for association, the A/C variant located in intron-1 (rs12794795) exhibited statistically significant association only with diastolic blood pressure p = 0.018) after accounting for the trait-specific covariate effects. The Cys311Ser variant failed to show statistically significant association with any of the phenotypes examined. Conclusion: In conclusion, the variants examined at the PON2 locus in Mexican
Americans do not appear to be a major contributor to T2DM, cardiovascular or renal disease risk, SHP099 although they exhibited a small effect on the blood pressure values. Copyright (C) 2009 S. Karger AG, Basel”
“Short episodes of high intensity exercise transiently increase serum levels of BDNF in
humans, but serum levels of BDNF at rest appear to be lower in more physically active humans with greater levels of energy expenditure. The relationship between serum BDNF concentration, cardio-respiratory fitness VE-822 mw (Astrand-Rhyming test estimated VO(2) max)and volume of long-term, regular exercise and sporting activity (Baecke Habitual Physical Activity Index) was investigated in 44 men and women between the age range of 18-57 years. In this group an inverse relationship between resting serum BDNF concentration and measures of both estimated VO(2) max (r = -0.352; P < 0.05) and long-term sporting activity (r = -0.428, P < 0.01) was found. These results indicate that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans. This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“This study was designed to assess the predictors of a higher blood pressure (BP) in a clinical setting in a prospective cohort of normotensive children recruited in an outpatient pediatric clinical setting in Southern Brazil. The study evaluated 443 children 3-12 years of age.
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