They further found that H19 was associated with angiopoietin (ANG) and fibroblast growth factor-18 (FGF-18), whose functions are involved in tumor growth and proliferation selleck bio [20]. To understand the molecular mechanism by which H19 increases gastric cancer cell growth, Yang et al. examined whether H19 affects the function of the tumor suppressor p53 [27]. They found that H19 was associated with p53, and that this association resulted in partial p53 inactivation [27]. Contrary to H19, uc001lsz expression level in gastric cancer tissues was found to be markedly lower (Figure 3A). As showed in Figure 3C, the expression of uc001lsz in gastric cancer cell lines (AGS and MGC-803) is lower than that in gastric epithelial cell (GES-1), but there was no significant different between SGC-7901 and GES-1.
Maybe the low grade malignancy of SGC-7901 leads to this result. More importantly, a greater association between uc001lsz expression and TNM stage was found (Table 2). These results confirmed uc001lsz as an important player in inhibiting the development of gastric cancer. As we known, many lncRNAs are transcribed close to or within protein-coding loci, which has strengthened the hypothesis that lncRNAs may have cis-acting effects within these loci. But uc001lsz may have trans-acting effect within its adjacent protein-coding loci. MUC2, a member of the mucin protein family of genes, is located next to UC001LSZ. The MUC2 is secreted onto mucosal surfaces, where it is secreted from goblet cells in the epithelial lining into the lumen of the stomach [34].
As reported, MUC2 was high expression in gastric cancer [35]. Although uc001lsz seems playing as tumor suppressor gene in gastric cancer and many other types of tumors, it may play different role in prostate cancer where uc001lsz was highly expressed (Figure 3C). Molecular tumor biomarkers are vital diagnostic and prognostic tools. Our data show that the expression of uc001lsz was aberrant in early gastric cancer and gastric precancerous lesions (Figure 5A). And the extraordinary changes maybe appear in the precancerous lesions (Figure 5B). This investigation indicates that uc001lsz may be a candidate biomarker of gastric cancer. Conclusions In summary, we depict an lncRNA expression profile that associated with gastric Dacomitinib cancer. The overexpression of H19 in gastric cancer cell lines and tissues suggests that H19 may be participated in gastric cancer. The reduced expression of uc001lsz in gastric cancer cell lines and tissues, its associations with TNM stage, and its dysregulation in early cancer and precancerous lesions suggest that uc001lsz may have an important role in gastric cancer occurrence and be a potential biomarker for the diagnosis of early gastric cancer.
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