Also, it has been reported that some ill persons chose to embark on cruises with the intention of dying at sea.19 Finally, deaths aboard airlines are underreported because national or local laws often prohibit pronouncing a traveler dead on an aircraft.21 Although reporting to CDC quarantine stations is passive, and not all deaths in arriving international travelers are reported to QARS, the results of our investigation and others indicated that vaccine-preventable and tropical diseases are not major causes of death in international travelers.5,6 ,8–11,13–15

This finding may reflect advancements in global public health, improved adherence Galunisertib manufacturer of travelers to appropriate pre-travel guidance, the presence of pre-existing immunity, or a low risk of exposure to infectious pathogens by travelers, especially cruise ship passengers. It is unclear how many of the 26 fatal infections were acquired before rather than during travel. PD-1 antibody It is unknown whether the deaths in our investigation, excluding those related to injury, could be attributed to or were coincidental to international travel, or if medical care available at U.S. hospitals, but unavailable on cruise ships, could have averted some of these deaths. Using Peake et al.’s23 data, we calculated a mortality rate for North

American cruise ship passengers of 9.8 deaths per million passenger-nights among four ships in one cruiseline. In contrast, our investigation found a much lower mortality rate for cruise ship passengers (0.6 deaths per million passenger-nights). Differences in passenger populations and methodology Phenylethanolamine N-methyltransferase (Peake’s active case finding vs. CDC’s passive surveillance) may explain some of this discrepancy. The significant increase in death rates in cruise ship passengers from years 1 to 3 in our investigation may represent improved reporting to CDC by airlines, cruise lines, and CBP due to increased CDC training to encourage reporting. It has been suggested that increasing numbers of travelers may

have chronic or terminal illnesses, but there are no data to confirm this hypothesis. Mortality rates in cruise ship passengers were lowest during the third quarter in all 3 years, predominantly due to decreases in cardiovascular mortality. This third-quarter reduction could reflect the known seasonality of myocardial infarctions, which peaks in the winter and drops in the summer.42 Also, there may be a seasonal variation in cruise ship passenger demographics or activities which affect cardiovascular mortality. We were unable to obtain demographic data from the cruise industry to confirm any variation. An in-flight death rate of 0.31 deaths per million air passengers was calculated from 1977 to 1984 data reported by International Air Transport Association (IATA) members, which is consistent with our results.20 Other in-flight death rates have been reported to be 0.

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