The frequency of treatments with symptomatic hypotension was reduced from 32% +/- 23% in standard HD to 24% +/- 21% with BV-controlled UF (p = 0.04). Changes in blood pressure and heart rate from start to end of the HD session were not different between the 2 treatment modes.

Conclusions: This crossover study showed improved intradialytic stability with BV-controlled UF, compared with standard HD.”
“A crisis AMPK inhibitor continues to

brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various suggestions for both the expansion and broader adoption of modeling and simulation (M&S) methods. We suggest strategies and scenarios intended to enable new M&S use cases that directly engage R&D knowledge generation

and build actionable mechanistic insight, thereby opening the door to enhanced productivity. What M&S requirements must be satisfied to access and open the door, and begin reversing the productivity decline? Can current methods and tools fulfill the requirements, or are new methods necessary? We draw on the relevant, recent literature to provide and explore answers. In so doing, we identify RWJ 64809 essential, key roles for agent-based and other methods. We assemble a list of requirements necessary for M&S to meet the diverse needs distilled from a collection of research, review, and opinion articles. We argue that to realize its full potential, M&S should be actualized

within a larger information technology frameworka dynamic knowledge repositorywherein models of various types execute, evolve, and increase in accuracy over time. We offer some details of the issues that must be addressed for such a repository to accrue the AZD8055 inhibitor capabilities needed to reverse the productivity decline. (C) 2013 Wiley Periodicals, Inc.”
“The occurrence of intra-abdominal hypertension (IAH), as well as its promoting factors in cardiac surgery, has been poorly explored. The aim of the present study was to characterize intra-abdominal pressure (IAP) variations in patients undergoing cardiac surgical procedures, and to identify the risk factors for IAH in this setting.

All consecutive adult patients requiring postoperative intensive care unit admission for > 24 h were enrolled. Demographic data, pre-existing comorbidities, type and duration of surgery, cardiopulmonary bypass (CPB) use and duration, perioperative IAP, organ function and fluid balance were recorded. IAH was defined as a sustained increase in IAP > 12 mmHg. Multivariate logistic regression and stepwise analyses identified the baseline and perioperative variables associated with IAH.

Of 69 patients, 22 (31.8%) developed IAH.

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