9) 45 (80.4) 32 (91.4) 0.31 72 (88.9) 52 (86.7) 39 (76.5) 0.69 0.06 Selleck BAY 11-7082 G eFT508 datasheet carrier 31 (17.1) 11 (19.6) 3 (8.6) 0.67 9 (11.1) 8 (13.3) 12 (23.5) MMP-9 A carrier 78 (42.6) 19 (33.3) 15 (41.7) 0.21 0.92 25 (30.5) 22 (36.1) 22 (43.1) 0.48 0.14 G/G 105 (57.4)
38 (66.7) 21 (58.3) 57 (69.5) 39 (63.9) 29 (56.9) TIMP-1 ♀ T carrier ♂ T 148 (80.9) 41 (73.2) 29 (80.6) 0.22 0.97 46 (56.8) 31 (50.8) 26 (51.0) 0.48 0.51 C/C C 35 (19.1) 15 (26.8) 7 (19.4) 35 (43.2) 30 (49.2) 25 (49.0) TIMP-2 C carrier 54 (30.2) 17 (32.1) 10 (28.6) 0.79 0.85 27 (33.3) 20 (32.3) 13 (25.5) 0.89 0.34 G/G 125 (69.8) 36 (67.9) 25 (71.4) 54 (66.7) 42 (67.7) 38 (74.5) Abbreviations: DU, duodenal ulcer; GU, gastric ulcer. The p value was determined by Fisher’s exact test or χ2 test. a indicated significance with p < 0.05 of such parameter between gastritis and duodenal ulcer; b between gastritis and gastric ulcer. Genotype distribution of SNP in cases and control was in Hardy-Weinberg equilibrium (p < 0.05). There was a higher rate of MMP-3 6A6A genotype in patients with duodenal ulcers than in patients with gastritis (87.7% vs. 74.9%, p < 0.05). H. pylori-infected subjects with the MMP-3 6A6A genotype had a 2.4-fold (95% CI: 1.02-5.66)
increased risk of duodenal ulcer in females compared to those with the 5A carrier. Because www.selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html TIMP-1 genotypes modulated MMP-3 activity, it was further tested whether the MMP-3-1612/TIMP-1372 Combined genotypes contributed to increased
risk of duodenal ulcers in females. The combined MMP-3/TIMP-1 genotype as 6A6A/CC had a 3.6-fold (p < 0.05) increased risk of duodenal ulcer in H. pylori-infected female (Table 4). Table 4 Risks of combined MMP-3/TIMP-1 genotype for developing duodenal ulcer in females Gastritis Duodenal ulcer OR (95% CI) P MMP-3 -1612 - TIMP-1 372 n (%) n (%) 5A carrier - T carrier 39 (88.6) 5 (11.4) 1 - 5A carrier - C/C 7 (77.8) 2 (22.2) 2.23 (0.36 - 13.85) 0.59 6A/6A - T carrier 109 (75.2) 36 (24.8) 2.58 (0.94 - 7.03) 0.06 6A/6A - C/C 28 (68.3) 13 (31.7) 3.62 (1.16 - 11.32) 0.03 The p value was determined by Fisher's exact test. OR, odds ratio; 95% CI, 95% confidence interval. Discussion This study surveyed AZD9291 concentration whether the bacterial factor dupA in H. pylori or single nucleotide polymorphisms of MMPs and TIMPs correlated with the susceptibility of gastroduodenal ulcers after H. pylori infection. It shows a rather low prevalence (23.8%) of dupA-positive H.
No related posts.