Enteroviruses are of high clinical relevance with coxsackievirus B3 (CVB3), which can cause heart-muscle infection, being an 3-Methyladenine molecular weight important member.
In addition, Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and herpangina that can also cause severe neurological disease including brainstem encephalitis and poliomyelitis-like paralysis [2], [3], [4] and [5]. Human rhinovirus (HRV) represents one of the most important etiological agents of the common cold [6]. Although HRV-induced upper respiratory illness is usually mild and self-limiting, there is increasing evidence linking HRV infection to more serious medical complications including asthma exacerbation [7]. To date, no effective antiviral therapies have been approved for either the prevention or treatment of diseases caused by viruses classified within the Picornaviridae family, including CVB3, EV71, and HRV [8]. In this regard, many trials have been conducted to find antiviral components from plants. Such trials have specifically selleckchem targeted plants with intrinsic defense mechanisms in the form of secondary metabolites against a broad range of viral infections, in contrast to adaptive immunity induced in mammals. Indeed, medicinal plants are gaining popularity as suitable alternative sources of antiviral agents because of their
multiple targets, minor side effects, low potentials to cause resistance,
and low costs [9], [10], [11], Nutlin-3 purchase [12] and [13]. Although several hundreds of plants with the potential to contain novel antiviral agents have been studied, a number of potentially useful medicinal plants still need to be evaluated and exploited for therapeutic applications against the genetically and functionally diverse virus families. Of these potential agents, we have focused on ginsenosides, which are some of the major components of the ginseng plant, Panax ginseng Meyer. The root of P. ginseng (Araliaceae) is the most well-known medicinal plant in the Asian region and is frequently used in traditional medicine [14]. Ginsenosides are triterpenoid glycosides containing dammarane [15], and are generally divided into two groups: the protopanaxadiol (PD) and protopanaxatriol (PT) ginsenoside groups. The sugar moieties in the PD group including Rb1, Rb2, Rc, Rd, Rg3, and Rh3 are attached at the 3-position of dammarane-type triterpenes, whereas the sugar moieties in the PT group including Re, Rf, Rg1, Rg2, and Rh1 are attached at the 6-position of dammarane-type triterpenes [16]. As the major components in ginseng, ginsenosides have various biological activities such as anticancer [17], antiaging [18] and [19], and antitumor activities [20]. Moreover, the antiviral activities of ginseng against influenza virus [15], norovirus [21], and HBV [22] have recently been reported.
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