To our knowledge, this is the first pediatric case of geniculate ganglion venous malformation presenting solely with conductive hearing loss. Proper management requires differentiating this condition from other geniculate and temporal bone lesions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Quantum-chemical method B3LYP/6-311++G(df,p) was applied to the study of complex formation between phenol and methanol. The complexes of molecules bound by the hydrogen bond possess enhanced donoracceptor and acid-base properties as

compared to monomer molecules. The reactions of phenol and methanol complexes with methyl isocyanate proceed through a concerted late asymmetric transition state by the type of nucleophilic addition. The most kinetically and thermodynamically favorable transformation selleck products is the process involving the complex “”phenol-acceptor, methanol-donor.”"

Phenol compounds are able to catalyze the addition of alcohols to isocyanates.”
“Background: Chronic obstructive pulmonary disease (COPD) AZD8055 is characterized by airway inflammation and is associated with acute exacerbations. Macrolide antibiotics have been shown to exhibit anti-inflammatory effects in some chronic airway inflammatory diseases. Objective: The aim of this study was to assess the effect of treatment with erythromycin on airway inflammation and health outcome in COPD patients. Methods: We conducted a randomized, placebo-controlled, double-blind trial of erythromycin for a period of 6 months. Thirty-six COPD patients were randomized to treatment with oral erythromycin (125 mg, three times/day) 3-Methyladenine molecular weight or placebo. The primary outcomes were neutrophil number in sputum and

exacerbations. Results: Thirty-one patients completed the study. At the end of treatment, neutrophil counts in the sputum were significantly decreased in the group treated with erythromycin compared with placebo-treated patients (p = 0.005). Total cells in the sputum and neutrophil elastase in sputum supernatant were also significantly decreased in those treated with erythromycin compared with the placebo group (p = 0.021 and p = 0.024, respectively). The mean exacerbation rate was lower in the erythromycin group than in the placebo group (relative risk = 0.554, p = 0.042). Kaplan-Meier survival analysis showed that erythromycin significantly delayed the time to the first COPD exacerbation compared with placebo (p = 0.032). Conclusions: Erythromycin treatment in COPD patients can reduce airway inflammation and decrease exacerbations and may therefore be useful in the management of COPD. Copyright (C) 2010 S. Karger AG, Basel”
“Nasal dermoid sinus cysts are the most common congenital midline nasal lesions. The frequency of intracranial extensions varies from 5% to 45%.

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