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“The oral administration of various extracts (hexane, ethyl acetate and methanol) of Tinospora cordifolia stem (TCS) were found to have potent antidiabetic activity that reduces blood sugar level in streptozotocin-(STZ) induced diabetic rats. In this study, the chronic
(100 days) antihyperglycemic effect of the extracts at a dose of 250 mg/kg b.w.p.d of TCS were investigated. Insulin was used as a reference drug at a dose of 3 I.U/kg. b.w.p.d. Fasting blood glucose, glycosylated hemoglobin (HBA(1)C), serum insulin, C-peptide and liver enzymes levels were evaluated in normal, diabetic and treated rats. Supplementation of methanol extract significantly reduces the fasting blood glucose level when compared to other 2 extracts. Moreover this supplementation significantly decreases the glycosylated hemoglobin selleck kinase inhibitor level as compare to diabetic control (p < 0.001), reduced glucokinase and increased glucose-6-phoaphatase activity were reversed significantly by the treatment of TCS methanol extract in respect to diabetic group. In the TCS treated groups, the insulin and C-peptide levels were improved which shows the regeneration of -cell which secretes insulin, histopathological studies of pancreas of TCS methanol extract treated groups substantiate the regenerating capacity of extract.”
“3000 angstrom Fe3O4 (magnetite)
thin films were simultaneously grown on (001) MgO single crystal substrates with and without 30 angstrom buffer layers SHP099 of Fe, Cr, Mo, and Nb. For all samples, the Verwey transition temperature (T-V) occurs between 119 and 125 K, indicating good oxygen stoichiometry. We observe highly oriented (001) Fe3O4 with Mo and no buffer layer, reduced (001) texture with Nb and Fe, and polycrystalline growth with Cr. Mo, Cr, and unbuffered magnetite show typical magnetic behavior, whereas Nb and Fe buffers lead to anomalous magnetic properties that may be due to interfacial reactivity. (C) 2010 American Institute of Physics. [doi:10.1063/1.3350910]“
“P>We
investigated whether children after WZB117 in vivo heart- (HTx) or heart-lung transplantation (HLTx) show protective antibody levels against recommended vaccinations, whether vaccination schedules are completed and which factors influence serologic immunity. We performed a cross sectional ELISA – quantification of specific antibodies in 46 patients after pediatric thoracic Tx. Findings were correlated to vaccination history, age at Tx, clinical course and immunosuppressive regimen. We found protective antibody levels against diphtheria in 74% of patients, against tetanus in 22%, against Haemophilus influenzae type b in 30% and against Streptococcus pneumoniae in 59%. Antibody concentrations against live attenuated vaccines were significantly lower in children transplanted in the first 2 years of life.
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