With the availability of high-risk pools, HCPs indicated that they would switch patients from on-demand to prophylaxis/initiate prophylactic treatment for patients whose treatment otherwise may have been delayed (17%). To our knowledge, this is the first comprehensive study to document the impact of the economic downturn and the perceived impact of health care reform on the haemophilia A patient population
in the USA. Many Americans faced financial challenges as a result of the recent economic downturn. According to the National Council of Aging, approximately one-fourth of Americans with chronic diseases delayed or did not seek needed care for financial reasons during the economic downturn [22]. Although information HSP assay about treatment modifications made by Americans with various conditions, such as heart disease, diabetes and cancer care as a result of financial constraints imposed by the downturn, has previously been reported [20], it did not provide any insight about similarities or unique financial challenges experienced by patients
with rare conditions, including haemophilia A. It is unknown how haemophilia A patients fare in the current economic environment and how health care reform would Crizotinib datasheet impact haemophilia A treatment. Based on studies by Du Treil et al. and De Mooerloose et al., haemophilia A patients not adherent to their treatment regimen (i.e. skipping doses or not following up with routine examination) are less likely to have optimal clinical outcomes and quality of life [14, 24]. Therefore, one of the goals of this survey study was to evaluate how haemophilia patients, caregivers and HCPs were impacted by both the recent economic downturn and health care reform. The results showed that haemophilia A patients, caregivers and HCPs perceived the economic downturn as negatively
impacting haemophilia A care. Haemophilia A patients in this survey commonly reported changes to their treatment as a result of financial challenges (e.g. loss of job, income and/or health insurance; decrease in health insurance benefits, increase in health insurance premiums, increase in OOP costs in 2009 and 2010). These barriers resulted in suboptimal treatment G protein-coupled receptor kinase choices by patients, such as delaying or skipping visits to their HCP, reducing their treatment frequency, skipping a dose of medication and/or not filling a prescription due to financial constraints. These findings are consistent with the perceptions expressed in a poll by Harvard School of Public Health that focused on the impact of the economic downturn on heart disease, diabetes and cancer [20]. An estimated 43% of Americans with heart disease, 42% with diabetes and 21% with cancer indicated that the economic downturn interfered with their ability to manage their condition [20].
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