05); normal ovary showed a lower score of PAI-1, but ovarian cancer showed higher score, significant differences were observed (P < 0.05).
Bar graphs show the positive score of DLC1 and PAI-1 protein. KU55933 clinical trial Figure 3 Expression of DLC1 and PAI-1 in normal ovarian tissue (A) and ovarian cancer tissues (B) detected by Western Blotting. Interest bands were presented by Western Blotting from different tissue samples, each protein band represents one random specimen tissue. Normal ovary showed a higher expression of DLC1, but ovarian cancer showed lower expression; normal ovary showed a lower expression of PAI-1, but ovarian cancer showed higher expression. Figure 4 Bar graph of the Western Blotting assay. Each bar represents the relative value of DLC1 and PAI-1 protein, significant differences were Regorafenib concentration observed between normal ovary and ovarian carcinoma (P < 0.05). Association of DLC1 and PAI-1 expression with the clinicopathologic characteristics of ovarian cancer As shown in Table 1, the expression of DLC1 and PAI-1
were significantly associated with FIGO stage and lymph node metastasis in ovarian carcinoma. In addition, DLC1 was also related with ascites, and PAI-1 was related with histological differentiation. Table 1 Relations between expression of DLC1 and PAI-1 in ovarian cancer and clinical characteristics of epithelial ovarian cancer Group n DLC1 χ 2 P PAI-1 χ 2 P + % + % Age buy BI 10773 <50 27 11 40.7 0.182 0.670 20 74.1 0.715 0.398 ≥50 48 22 45.8 31
64.6 Histological type Serous 52 21 40.4 0.900 0.343 35 67.3 0.037 0.847 L-NAME HCl Mucinous 23 12 52.2 16 69.6 FIGO stage I ~ II 32 19 59.4 5.355 0.021* 16 50.0 8.311 0.004* III ~ IV 43 14 32.6 35 81.4 Histological differentiation G1 16 9 56.3 5.372 0.068 7 43.8 6.359 0.042* G2 25 14 56.0 17 68.0 G3 34 10 29.4 27 79.4 Lymph metastasis YES 33 9 27.3 6.692 0.010* 28 84.8 7.688 0.006* NO 42 24 57.1 23 54.8 Ascites YES 52 17 32.7 8.799 0.003* 37 71.2 0.775 0.379 NO 23 16 69.6 14 60.9 *Chi-square test. Compared with normal ovarian tissues P < 0.05. The correlation between DLC1 and PAI-1 in epithelial ovarian carcinoma Among the 75 specimens of EOC, there were 15 positive for DLC1 and negative for PAI-1, as well as 33 negative for DLC1 and positive for PAI-1. This result suggests a negative correlation between the expression of DLC1 and PAI-1 (r = −0.256, P = 0.027). Associations of DLC1 and PAI-1 expression with the prognosis of ovarian cancer Partial Correlate analysis showed the expression of DLC1 was negatively related with FIGO stage (P = 0.015), ascites (P = 0.043), lymph node metastasis (P = 0.021), but positively related with prognosis (P = 0.009). The expression of PAI-1 was positively related with FIGO stage (P = 0.011), histological differentiation (P = 0.
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