16 and 17 The structure of lornoxicam is given below. Figure options Download full-size image Download as PowerPoint slide Lornoxicam structure indicates that the molecule is highly aromatic and no functional group much to the aqueous solubility. It is essential to assess relative role of nonpolar, polar, and hydrogen inhibitors bonding, with its total solubility parameter. Present communication reports the solubility behavior
of lornoxicam in individual solvents ranging from nonpolar (hexane), semi-polar (alcohol) to polar solvent (water) by using the current approaches. The additional support was obtained from the theoretical group contribution methods.18 and 19 Lornoxicam was gift sample (Hetero Drugs, Hyderabad, selleck inhibitor India). Solvents and other chemicals were of analytical grade (S.D. fine chemicals Ltd,
Mumbai). The lornoxicam solubility was determined in saturated solutions of pure solvents. The mixtures with excess drug were shaken in an orbital shaker bath held at 25 ± 0.5 °C. The mixtures were filtered after 72 h and diluted with 0.05 N sodium hydroxide solution for drug content estimation using UV–visible spectrophotometer at 376 nm.20 The enthalpy of fusion was determined by differential scanning calorimeter by heating at 2 °C per min and at the fusion temperature PFI-2 of 479.8 °K. These data was taken to calculate the ideal mole fraction solubility of lornoxicam. Melting point was determined in open capillaries. Experimentally floatation technique was used to determine the molar volume21 and theoretically by Fedors group contribution approach.18 Theoretically total solubility parameter of lornoxicam was calculated by the methods of Fedors and Hoy18 and 19 and partial solubility parameter values using Van Krevelan
method.22 The solubility parameters of the solvents were collected from the literature, shown (Table 1). The solubility parameter (δT), for lornoxicam is also calculated by different statistical methods based on the experimental Electron transport chain data. Required in-house software was developed using GW-BASIC for solubility calculations. The dependent variables were fitted to the three-parameter equation, Flory–Huggins size correction equation, and four–parameter equation. Lotus 1-2-3 was used for multiple regression analysis. F-ratio is calculated using standard statistics where the parameter ‘s’ represents the standard error of the ‘y’ estimate and the confidence level of 99%. The ideal mole fraction solubility of lornoxicam obtained using molar heat of fusion (ΔHf = 54.2857 kJ/mol). The melting point To was 206–211 °C by open capillary method and 206.8 °C by DSC. This value was closer to the literature value. 16 The ideal mole fraction solubility of lornoxicam is 2.4839 × 10−4 based on enthalpy of fusion, as was considered in case of piroxicam.
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