2) 33(68.7) 51(62.2) 0.04 Female 9(36) 7(77.8) 15(31.3) 31(37.8) Age < 20 6(24) 0(0) 7(14.6) 13(15.8) 0.012 20-39 7(28) 6(66.7) 8(16.7) 21(25.6) 40-59 9(36) 0(0) 21(43.7) 30(36.6) > = 60 3(12) 3(33.3) 12(25) 18(21.9) Tumor size < = 5 cm 16(64) 2(22.2) 13(27.1)
31(37.8) 0.004 >5 & < = 10 cm 7(28) 3(33.3) 12(25) 22(26.8) >10 & < = 15 cm 0(0) 4(44.4) 11(22.9) 15(18.3) >15 & < = 20 cm 2(8) 0(0) 7(14.6) 9(11) >20 cm 0(0) 0(0) 5(10.4) 5(6.1) Tumor location Upper limb 8(32) 0(0) 5(10.4) 13(15.8) 0.009 Lower limb 9(36) 4(44.4) 22(45.8) 35(42.7) Thorax 6(24) 5(55.6) 7(14.6) 18(21.9) Head & neck 1(4) 0(0) 1(2.1) 2(2.4) Retroperitoneum 1(4) 0(0) 13(27.1) 14(17.1) Plane of tumor PF 2341066 Subcutis 21(84) 6(66.7) 16(33.3) 43(52.4) < 0.001 Muscular plane 3(12) 3(33.3) 17(35.4) 23(28.0) Body cavity 1(4) 0(0) 15(31.2) 16(19.5) Circumscription No 5(20) 7(77.8) 32(66.7) 44(53.7) < 0.001 Yes 20(80) 2(22.2) 16(33.3) 38(46.3) Capsulation
No 20(80) 9(100) 44(91.7) 73(89.0) 0.232 Yes 5(20) 0(0) 4(8.3) 9(11) Necrosis No 25(100) 7(77.8) 29(60.4) 61(74.4) < 0.001 Yes 0(0) 2(22.2) 19(39.6) 21(25.6) Figure 1 Pathologic features of benign, intermediate, and malignant soft tissue tumors. Benign tumor (A) shows cystic degeneration and nuclear palisading and (B) shows nests of granular cells Etomoxir concentration separated by fibrocollagenous tissue. The intermediate grade tumors (C) shows solid, cellular lobules consisting of plump DNA ligase endothelial cells lining tiny rounded vascular spaces with inconspicuous and (D) shows proliferation of spindle cells in inflammatory background. The malignant soft tissue tumors (E) shows epithelioid cells
arranged in nests, with a pseudoalveolar pattern and (F) shows lobulated vascular neoplasm composed of small blue round cells in sheets and rosettes. Image magnifications are 400×. Immunohistochemistry for STAT3 and DMXAA solubility dmso pSTAT3 Overexpression of STAT3 and p-STAT3 correlates with tumor grade Immunohistochemical staining revealed both cytoplasmic and nuclear localization of STAT3 and pSTAT3 in benign, intermediate, and malignant soft tissue tumors [Figure 2]. Two of 25 benign tumors expressed mild cytoplasmic positivity for STAT3 whereas 6 intermediate tumors exhibited both mild and moderate cytoplasmic positivity for STAT3. Thirty seven of the 46 malignant tumors showed intense STAT3 expression in the cytoplasm whereas the remaining 9 tissues showed moderate and mild cytoplasmic positivity. pSTAT3 expression was not observed in benign tumors. Both mild and moderate cytoplasmic expression of pSTAT3 was observed in intermediate tumors and only malignant tumors exhibited intense cytoplasmic expression for pSTAT3.
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