As such, the purpose of this study was to estimate the rates of psychotropic concomitant medication (PCM) use in six European countries and to identify patient characteristics associated with PCM use among CHIR-99021 order children and adolescents receiving a product label-indicated ADHD treatment. 2 Methods 2.1 Study Data and AZD8931 cost Selection Criteria This retrospective cohort study is based on a review and data abstraction of patient medical records by their treating physicians in six Western European countries: the UK, France, Germany, Italy, the Netherlands, and Spain. A convenience sample of pediatricians, neuropediatricians, child and/or adolescent psychiatrists, and pediatric neurologists who treated patients

with ADHD was identified from physician directories maintained by local country medical associations and physician telephone directories. Physicians included in the database were recruited by telephone or email and directed to an Internet-based questionnaire to potentially participate in the study. Physicians with between 3 and 30 years of experience were eligible for inclusion if they managed a minimum of five patients per month with ADHD between the ages of 6 and 17 years and were primarily responsible for making ADHD-related treatment decisions for the patient. Institutional Review Board study protocol review and exemption was obtained prior to study data collection.

All data were entered by the physician via an online questionnaire translated into the language of the country. Physicians were asked to complete an ADHD patient

chart review for up to five of their most recent patients who Dinaciclib price met the patient study age criterion, had a documented diagnosis of ADHD between January 1, 2004 and June 30, 2007, and had at least 2 consecutive years of follow-up post-diagnosis (e.g., medical record information available). Patients were also required to have received either pharmacologic treatment or behavioral therapy following the ADHD diagnosis. Eligible patient PLEKHB2 charts could have a diagnosis of ADHD only, or ADHD combined with the presence of other behavioral symptoms (e.g., anger, irritability), related behavioral disorders (e.g., ODD), or psychiatric co-morbidities (e.g., autism, anxiety). Symptom impairment scale responses were evaluated in the range of 1 being the “lowest impairment” to 10 being the “highest impairment.” Patient charts were excluded if there was evidence of enrollment in a randomized clinical trial during the time of the data abstraction. For purposes of this analysis, additional criteria were applied to increase the likelihood that PCM was used for ADHD. Patients with pre-existing epilepsy or Tourette syndrome were excluded as these are concomitant conditions that may warrant the use of psychotropic medications such as neuroleptic or antiepileptic drugs, which could have been used for both ADHD and these concomitant conditions.

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