Oct-4 expression in tumor Navitoclax tissue and differentiation of tumor cells were strongly associated with cancer-associated death. Notably, an Oct-4 expression level less than the median histoscore (25.80) was associated with improved survival (HR, 1.011), whereas elevated Oct-4 expression was associated with shorter cumulative survival (p = 0.009). A Kaplan-Meier plot showed a prominent difference in survival estimates for patients with high versus low Oct-4 expression in tumor tissue; this difference corresponded to a median survival of 18.2 ± 6.0 months for patients with high GW786034 order Oct-4 expression compared with a median survival of more than 24.7 ± 9.1 months for patients with low Oct-4 expression (Figure 3A). 27.3 ± 9.6 months; Figure 3B) and the www.selleckchem.com/products/Temsirolimus.html squamous cell carcinoma subset (20.7 ± 9.5 vs. Table 2 Univariate and multivariate analyses of individual variables for correlations with overall survival: cox proportional hazards model Variables Univariate Multivariate   HR 95%CI P HR 95%CI P Age 0.988 0.969-1.008 0.231 1.001 0.978-1.025

0.922 Gender 0.852 0.517-1.405 0.530 0.525 0.305-0.906 0.121 Smoking 1.179 0.740-1.880 0.489 1.277 0.743-2.195 0.376 Histological type 1.087 0.697-1.695 0.713 1.168 0.706-1.932 0.546 Histological differentiation 3.727 2.139-6.495 < 0.001 3.666 1.937-6.939 0.001 Local advance 1.282 0.920-1.731 0.149 1.222 0.928-1.609 0.153 Lymph node metastasis 1.487 1.148-1.927 0.003 1.042 0.743-1.461 0.813 Oct-4 expression 1.105 1.007-1.024 < 0.001 1.011 1.003-1.020 0.009 Age 0.990 0.963-1.018 0.482 1.014 0.978-1.051 0.450 Gender 0.786 0.408-1.512 0.470 0.296 0.087-1.008 0.052 Smoking 1.231 0.646-2.346 0.527 0.733 0.237-2.265 0.590 Histological type 0.785 0.408-1.512 0.470 0.869 0.386-1.956 0.735 Vasopressin Receptor Histological differentiation 1.428 0.701-2.910 0.327 1.418 0.591-3.405 0.434 Local advance 1.191 0.780-1.817 0.418 0.934 0.560-1.558 0.793 Lymph node metastasis 1.217 0.833-1.778 0.310 1.560 0.976-2.495 0.063 Oct-4 expression 1.014 1.002-1.025 0.021 1.024 1.007-1.042 0.005 Age 0.994 0.965-1.024 0.688 1.005 0.967-1.044 0.801 Gender 0.790 0.395-1.580 0.505 0.401 0.166-0.966 0.096 Smoking 1.232 0.635-2.389 0.537 0.921 0.382-2.219 0.855 Histological type 1.439 0.767-2.700 0.257 1.247 0.598-2.600 0.556 Histological differentiation 1.925 0.934-3.969 0.076 1.962 0.791-4.868 0.146 Local advance 1.

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