Error bars represent 95% CI based on Kaplan�CMeier survival analyses. Satisfaction = smoking a lot more now to … The potential contributions of smoking to the natural course of nicotine dependence symptoms were examined next using the reference log-rank test to evaluate differences in the Kaplan�CMeier survival curve estimates between those smoking more or less than 100 cigarettes. These analyses showed that each symptom was significantly more prevalent among adolescents who had smoked more than 100 cigarettes by the end of the follow-up assessment, compared with those smoking fewer than 100 cigarettes. Among adolescents who had smoked more than 100 cigarettes, the vast majority of individual symptoms had a cumulative probability more than 75% by the end of the follow-up period.

Symptoms such as ��smoking a lot more now to be satisfied compared to when first smoked,�� ��increase in the amount smoked,�� and ��smoking to relieve restlessness and irritability�� reached a cumulative probability of 75% within 3 years of smoking initiation, whereas it took symptoms of ��smoking to keep from experiencing discomfort,�� ��willingness to go outside to smoke even in severe weather,�� ��craving without smoking for a few hours,�� and ��willingness to go outside in a rainstorm to get cigarettes�� 48�C54 months to reach a cumulative probability of 75%. Figures 3�C5 illustrate the cumulative probability of the three most commonly reported nicotine dependence symptoms.

Although these symptoms are reported by nearly all of the 100+ smokers, notably, more than 40% of adolescents smoking less than 100 cigarettes reported having ��increase in the amount smoked,�� and approximately 20% of those who smoked less than 100 cigarettes reported ��smoking to relieve restlessness and irritability�� and ��smoking a lot more now to be satisfied compared to when first smoked.�� A more detailed examination of order of onset of smoking milestones (i.e., 100 cigarettes and daily smoking) and nicotine dependence symptoms revealed that ��increase in the amount smoked,�� ��smoking to relieve restlessness and irritability,�� ��smoking a lot more now to be satisfied compared to when first smoked,�� and ��willingness to go outside to smoke even in severe weather�� occurred before daily smoking for more than one third of adolescents who had reached daily smoking levels (Table 1). The onset of several symptoms was similarly common before reaching 100 cigarettes smoked (i.e., ��increase in the amount smoked,�� ��smoking to relieve restlessness and irritability,�� ��smoking a lot more now to be satisfied compared to when first smoked,�� ��willingness to go outside to smoke even in severe weather,�� and ��smoking to keep from experiencing Anacetrapib discomfort��). Table 1.

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