Expression data are discussed in relation to the degree of salt tolerance in the different accessions. (C) 2011 Elsevier Masson SAS. All rights reserved.”
“Objective. Autophagy Compound Library high throughput The objective of this study was to estimate the association between the history of thyroid disease and the prevalence of oral lichen planus (OLP)/oral lichenoid lesions (OLL).
Study design. This was a retrospective case-control study using data from the medical records of 222 OLP/OLL patients and 222 age- and sex-matched controls who had visited the Institute of Dentistry, University of Oulu or the Oral
and Maxillofacial Department, Oulu University Hospital, from 1992 to 2001. Clinical characteristics of OLP/OLL lesions, other oral mucosal diseases, presence of cutaneous LP, history of allergies, medical history, and the use of regular medications were recorded. The relative odds of OLP, OLL, and OLP/OLL associated with selected patient characteristics were estimated by logistic regression.
Results.
History of any thyroid gland pathosis was found in 15% (n = 22) of the 152 cases with OLP, in 13% (n = 9) of the 70 cases with OLL, and in 8% (n = 18) of the control subjects; the estimated odds ratios (with 95% confidence intervals) being 2.12 (1.06 to 4.21) for OLP and 1.57 (0.62 to 3.73) for OLL. When confined to hypothyroidism only, this disease was found in 10% (n = 15) of the OLP cases, 9% (n = 6) of the OLL cases, and 5% (n = 11) of the controls; the estimated odds ratios being 2.39 (1.05 to 5.61) for OLP and 1.73 (0.56 to 4.90) for OLL.
Conclusion. The association selleck inhibitor of OLP/OLL and thyroid disease, especially between hypothyroidism and OLP, calls for further investigations in other populations and into the possible mechanisms behind this association. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:319-324)”
“Study Design. Human nucleus pulposus cells were activated with IL-6 plus IL-6 soluble
receptor (sR) in the presence or absence of IL-1 beta or TNF-alpha. Cell production of factors modulating the anabolic/catabolic balance of Trichostatin A the disc and proteoglycan synthesis were determined.
Objective. To evaluate NP cell response to exogenous IL-6, and how IL-6 modulates IL-1 and TNF-alpha actions in these cells.
Summary of Background Data. Interleukin-6 (IL-6) is produced by cervical and lumbar herniated discs and is associated with neurological symptoms of intervertebral disc degeneration. It upregulates catabolic gene expression and downregulates matrix protein gene expression in chondrocytes. However, no studies have evaluated the effects of IL-6 on disc nucleus pulposus (NP) cells.
Methods. NP cells from degenerated human discs were expanded in monolayer, maintained in alginate bead culture, and activated with IL-6 plus IL-6 soluble receptor (sR), in the presence or absence of IL-1 beta or TNF-alpha. Conditioned media was collected and analyzed for nitrite, PGE-2, TIMP-1, MMP-3, VEGF, and IL-8.
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