It is important that the advice provided by health authorities
to travelers, as well as residents, in the region reflects both the availability of registered products and published laboratory and field-based efficacy testing. The authors state that they have no conflicts of interest to declare. “
“Background. Diagnosis of acute schistosomiasis is often elusive in travelers. Serum schistosome DNA detection is a promising new diagnostic tool. Its performance is compared with current diagnostic procedures in a cluster of travelers recently infected in Rwanda. Methods. Recent infection with schistosomiasis was suspected in 13 Belgian children and adults, within 2 months after swimming in the Muhazi Lake, Rwanda. All were subjected to clinical examination, Liproxstatin-1 price eosinophil count, feces parasite detection, schistosome antibody RO4929097 in vivo tests [enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition assay (HAI)], and schistosome DNA detection in serum by real-time polymerase chain reaction. Results. All 13 patients, between 6 and 29 years old, had a high eosinophil count (median 2,120 µL−1; range 1,150–14,270). Seven of nine persons exposed for the first time developed
symptoms compatible with acute schistosomiasis. Eggs of Schistosoma mansoni were found in a concentrated feces sample of 9/13 (69%), with low egg counts (median 20 eggs per gram; range 10–120). BIBF-1120 Antischistosome antibodies (ELISA and/or HAI) were present in serum of 10/13 (77%) patients. Combining schistosome antibody tests and fecal microscopy demonstrated schistosomiasis in 11/13 (85%) patients. Schistosome-specific DNA was isolated in all 13 (100%) serum samples.
Conclusion. In this cluster of travelers with acute schistosomiasis, schistosome DNA detection in serum was able to confirm infection in all exposed persons. It clearly outperformed antibody tests and microscopic parasite detection methods as a qualitative diagnostic test. Schistosomiasis (or bilharziosis) is a tropical parasitic disease caused by blood-dwelling trematodes of the genus Schistosoma. Freshwater snails are the intermediate hosts, shedding cercariae infective to humans. Symptomatic acute schistosomiasis (AS), or Katayama syndrome, is a systemic hypersensitivity reaction directed against the maturing schistosomulae in the liver. AS is frequently reported in clusters of western travelers who have bathed in lakes and rivers in sub-Saharan Africa.1–4 Diagnostic confirmation is often elusive in suspected AS as well as in asymptomatic infection. Primary infection may cause a range of nonspecific symptoms that are often overlooked, or may remain asymptomatic.
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