Methods: A 74-year-old man was referred to our hospital with acute onset of jaundice superimposed on 1 month of constant dull right upper quadrant abdominal Selleck ICG-001 pain. A computed tomography scan revealed a 5 x 4 cm sized enhanced soft-tissue mass involving the duodenum and projecting into the
lumen along with hypervascular liver metastases. Preoperative diagnosis was a duodenal neuroendocrine tumor due to apparently typical features of a metastatic neuroendocrine tumor in the liver. Results: Then a pancreaticoduodenctomy with hepatic metasectomy was performed. Histopathological assessment revealed that the tumor was composed of elongated spindle-like cells positive for KIT and CD34, which had features consistent with the diagnosis of GIST, with a low mitotic count (0/50 HFP).
The excision margin of the duodenal mass was confirmed to be negative tumor cells. However, the pathologic surgical margin of liver metastases showed microscopically positive and the mitotic count was up to 20/50 HPF. The patient was discharged in satisfactory Dasatinib condition with the advice to take Imatinib considering the tumor to be metastatic malignant GIST. Conclusion: Although GISTs can arise at any location in the gastyrointestinal tract, duodenal GIST is a relatively rare entity in clinical practice. CT images are commonly used to investigate GIST-related metastasis. The most common appearance of liver metastases is that of hypodense lesions on non-contrast scanning and selleck inhibitor demonstrate less enhancement than surrounding liver. Thus, our duodenal GIST case, which produce hyper-enhanced metastases on all three of arterial, portovenous and delayed phases, presents an atypical CT feature and mimicked duodenal neuroendocrine tumor. Key Word(s): 1. GIST; 2. Duodenum; 3. Neuroendocrine tumor; 4. Hepatic metastases; Presenting Author: CHAO-ZHU HE Additional Authors: XIAO-HUA LIU, KUN-HE ZHANG, TING WANG, MEI-DI HU MEI-DI HU, PIAO-PING HU, DE-QIANG HUANG, NONG-HUA LV Corresponding Author: KUN-HE ZHANG Affiliations: the First Affiliated Hospital of Nanchang University; Jiangxi Institute of Gastroenterology & Hepatology
Objective: The detection of serum tumor markers is a simple and practical method for cancer screening and diagnosis, but it is not available in gastric cancer. Aptamers are artificial nucleic acid ligands of biological molecules selected via SELEX (systematic evolution of ligands by exponential enrichment) and valuable in diagnostic research. The present study was aimed at selecting and characterizing aptamers against gastric cancer serum for potential application in the diagnosis of gastric cancer. Methods: Aptamers were selected from a single-stranded random oligonucleotides library by using subtractive SELEX with pooled normal serum followed by conventional SELEX with pooled gastric cancer serum. Aptamers were isolated by cloning and sequencing.
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