Methods: One patient with hybrid constipation underwent S3 nerve permanent selleck chemicals neurostimulator implantation and electrostimulation. Results: The patient achieved
treatment success after 3 months of sacral nerve electromstimulation. After the 3 months follow-up, defecation frequency increased from 1 to 10 evacuations per week, about 2 times per day. Days per week with evacuation increased from 1 to 4. There was a decrease in time spent toileting (30 to 5 min), the perception of incomplete evacuation, subjective rating of abdominal pain and bloating. Cleveland Clinic constipation score decreased from 20 to 10. Visual analogue scale (VAS) score increased from 8 to 70. Quality of life significantly improved. Conclusion: SNS is effective in the treatment of hybrid constipation. Quality of life significantly improved. Key Word(s): 1. nerve stimulation; 2. hybrid constipation; 3. implantation; 4. neural regulation; Presenting Author: MULIA YIU Additional Authors: NANA SUPRIANA, MURDANI ABDULAH, DADANG MAKMUN Corresponding Author: MULIA YIU Affiliations: The University of Indonesia Objective: Radiation proctitis is frequently occured as a complication of radiotherapy for pelvic malignancies. Unlike acute radiation proctitis that is usually self-limiting, chronic radiation proctitis (CRP) can impact on quality of life, increase morbidity and even mortality of the patients. The aim of this study
was to evaluate the incidence and risk factors selleck products of CRP after radiotherapy in patients with cervical cancer. Methods: We performed a detailed retrospective analysis of cervical cancer patients who had radiotherapy in our institution from January to December 2010. Data on patient- and treatment-related factors, as well as CRP as late complication of radiotherapy were collected from patients’ medical records. Results: During that period of time, 234 patients met the criteria for this study. With a median follow-up of 30 months, 12 patients (5.1%) developed CRP (6 proctitis, 6 proctosigmoiditis). CRP occured 7–29 months after completion of radiotherapy (median 14.5 months); 87% of all CRP occured
上海皓元医药股份有限公司 within 2 years after radiotherapy. By Kaplan-Meier method, the actuarial probability of being free from CRP at the 29th month after radiotherapy was 93%. Multivariate Cox regression analysis demonstrated that the independent risk factors for CRP were total rectal-received dose > 65 Gy and age ≥60 with Hazard Ratio 7.96 (CI 2.30–27.50, p = 0.001) and 5.42 (CI 1.65–17.86, p = 0.005) respectively. Conclusion: Cervical cancer patients with age ≥60 and received more than 65 Gy of total rectal-received dose have a high probability of developing CRP. Despite the low incidence, thorough planning of the irradiated field and patient selection are crucial. Key Word(s): 1. cervical cancer; 2. radiotherapy; 3. radiation proctitis; 4.
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