Our data suggest that the variant IRGM allele thorough is associated with colon-only location, whereas in UC, the ECM1 variant was associated with cutaneous manifestations. None of the variants predicted resistance to steroids and azathioprine, efficacy of infliximab, or need for surgery. Application The new data presented from Eastern Europe might contribute to better understanding of genetic or environmental differences between populations and the association of those differences with disease susceptibility and phenotype. Terminology Vienna-Montreal classification: classification systems of disease phenotypes in CD. The classification assesses the age at presentation, disease location and disease behavior. The IRGM gene encodes an autophagy-inducing protein and plays an important role in host defense against intracellular pathogens.
NKX2-3 is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions. ECM1 encodes extracellular matrix protein 1, a glycoprotein expressed in small and large intestine. Notably, ECM1 strongly activates nuclear-��B signaling, a key immune regulator. Peer review The need to extend studies performed in the other parts of the world to Eastern Europe is valid, and provides a point for understanding subtle genetic or environmental differences between populations and the association of those differences with disease.
Acknowledgments Further Hungarian IBD Study Group members are: Simon Fischer, 1st Department of Medicine, Semmelweis University, Budapest; Zsuzsanna Erdelyi, Gabor Mester, Tunde Pandur, 1st Department of Medicine, Csolnoky F. County Hospital, Veszpr��m; Agota Kovacs, Laszlo Bene, 1st Department of Medicine, Erzsebet Hospital, Budapest; Ferenc Nagy, Klaudia Farkas, 1st Department of Medicine, University of Szeged, Szeged; Karoly Palatka, Zsuzsanna Vitalis, 2nd Department of Medicine, University of Debrecen, Debrecen; Laszlo Herszenyi, 2nd Department of Medicine, Semmelweis University, Budapest. Footnotes Supported by An unrestricted research grant from Abbott Laboratories; an OTKA postdoctoral fellowship (PF63953) (to Andrikovics H); the Bolyai Janos Postdoctoral Scholarship of the Hungarian Academy of Sciences (to Lakatos PL); No. NR/9219-3/2007 of the Internal Cilengitide Grant Agency of the Czech Ministry of Health (to Lukas M); Generation of the Czech IBD as well as control databases was enabled by the support of a grant given by the Czech Ministry of Education No. 2B06155 Peer reviewers: Dr.
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