Regarding the other parameters, in the majority of the temporal series there were no significant differences. In the cases where differences with statistical significance were detected, they were not unidirectional. The replacement of native forest by grasses can potentially increase tick abundance not by the modification of microclimatic conditions, but by increasing the tick-host
encounter rate due to a higher cattle density. The hypothesis that deforestation and introduction of exotic grasses affects the non-parasitic phase of R. BMS-777607 concentration microplus in northern Argentina was not supported. (C) 2013 Elsevier Ltd. All rights reserved.”
“The present study was carried out with a view to enhance the dissolution of poorly water-soluble BCS-class II drug aceclofenac by co-grinding with novel porous
carrier Neusilin US2. (amorphous microporous granules of magnesium aluminosilicate, Fuji Chemical Industry, Toyama, Japan). Neusilin US2 has been used as an important pharmaceutical excipient for solubility enhancement. Co-grinding of aceclofenac with Neusilin US2 in a ratio of 1:5 was carried out by ball milling for 20 h. Samples of co-ground mixtures were withdrawn at the end of every 5 h. and characterized for X-ray powder diffraction, differential Linsitinib scanning calorimetry, and Fourier-transform infrared spectroscopy. The analysis revealed the conversion of crystalline aceclofenac to its amorphous form upon milling with Neusilin US2. Further, in vitro dissolution rate of aceclofenac from co-ground mixture was significantly higher compared to pure aceclofenac. The accelerated stability study of co-ground mixture was carried out at 40A degrees C/75%RH for 4 weeks, and it showed that there was no reversion from amorphous to crystalline form. Thus, it is advantageous to use a porous carrier like Neusilin US2 in improvement of dissolution of poorly soluble drugs.”
“Interactions
between pharmaceutical ingredients play an important role in the development of drug formulations. It was the aim of our present studies to investigate drug-polymer interactions. Interaction of the antiviral drug acyclovir with polyethylenimines, polyvinylamines FG4592 and the non-ionic PVP was investigated using a modified equilibrium dialysis. The membrane was only permeable to free acyclovir, while polymers and acyclovir-polymer-associates did not pass through. Significant amounts of acyclovir were bound with the polyethylenimines. The formation of associates consisting of acyclovir and either PVP or polyvinylamine could not be demonstrated. In solutions of acyclovir and polyethylenimine (Mr=25000) the amount of bound drug is increased with increasing concentration of acyclovir. Between 7.9 mu g and 31.7 mu g take part in the formation of associates. Differences in the osmotic pressure of the solutions do not play an important role in the permeation of acyclovir.
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