The Ca2+ dynamics
models used are (1) a single Ca2+ pool; (2) two Ca2+ pools, respectively, for the fast and slow transients; (3) detailed Ca2+ dynamics with buffers, pump, and diffusion; and (4) detailed Ca2+ dynamics with buffers, pump, and diffusion compensation. Our results show that detailed Ca2+ dynamics models have significantly better control over Ca2+-activated K+ channels and lead to physiologically more realistic simulations of Ca2+ spikes and bursting. Furthermore, the compensating mechanism largely eliminates the effect of removing diffusion from the model on Ca2+ dynamics over multiple time scales.”
“”"Eight-and-a-half” syndrome is “”one-and-a-half” syndrome (conjugated horizontal gaze palsy and internuclear MK-2206 ophthalmoplegia) plus ipsilateral fascicular cranial nerve seventh palsy. This rare condition, particularly when isolated, is caused by circumscribed lesions of the pontine tegmentum involving see more the abducens nucleus, the ipsilateral medial longitudinal fasciculus, and the adjacent facial colliculus. Its recognition is therefore of considerable diagnostic value. We report a 71-year-old man who presented with eight and a half
syndrome associated with contralateral hemiparesis and hemihypesthesia, in which brain magnetic resonance imaging scans revealed a lacunar pontine infarction also involving the corticospinal tract and medial lemniscus. These features could widen the spectrum of pontine infarctions, configuring a possible “”nine” syndrome.”
“A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum. On the basis of chemical conversions and detailed analyses of (1)H and (13)C NMR spectra
including 2D NMR spectroscopic techniques, its structure was established as 3-[(O-beta-D-glucopyranosyl-(1 -> 3)-beta-D-glucopyranosyl-(1 -> 2)-O-[O-beta-D-glucopyranosyl-(1 SNX-5422 in vitro -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranosyl)oxy]2,6-dihydroxy-(2 alpha,3 beta,5 alpha,6 beta,25R)-spirostane. Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.”
“OBJECTIVE: To report the sublingual microcirculation observed using Sidestream Dark Field imaging in two children with dengue shock.
METHOD: Two children, aged 9 and 10 years, were admitted to the pediatric intensive care unit with dengue shock and multiple organ dysfunction. Sublingual microcirculation was assessed in each patient on the first and second days of shock and was assessed a final time when the patients were no longer in shock (on the day prior to extubation) using Sidestream Dark Field technology. The De Backer score and microvascular flow index were used for the analyses.
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