The hormonal and digestive changes induced by SG may have relevance
to the effects on metabolism.”
“Atrial septal defect (ASD) is a common cardiovascular malformation and an important contributor to substantial morbidity and mortality. Increasing evidence demonstrates that mutated NKX2-5, a gene encoding a homeobox transcription factor crucial to cardiogenesis, is a significant genetic GSK1838705A in vivo determinant for congenital ASD. Nevertheless, the genetic basis for ASD in a majority of ASD patients remains largely unknown. In the current study, the entire coding region of NKX2-5 was sequenced initially for 58 unrelated probands with familial ASD. The relatives of the probands harboring identified https://www.selleckchem.com/products/jq1.html mutations
and 200 unrelated control individuals were subsequently genotyped. Three novel heterozygous NKX2-5 mutations (p. P43 GfsX59, p. C46 W, and p. S179F) were identified respectively in three families with autosomal dominantly inherited ASD. These mutations, absent in 200 control individuals, cosegregated with ASD in the families that had complete penetrance. The findings expand the spectrum of mutations in NKX2-5 linked to ASD and contribute to genetic counseling, clinical interventions, and prenatal prevention of ASD for individuals with genetic susceptibility.”
“Objective: To determine the value of a single item on patients’ satisfaction with their condition for assessing outcome in four common surgical procedures.
Study Design and Setting: Four cohorts undergoing surgery for inguinal hernia (715), varicose veins (539), hip (8,383), or knee (10,187) disease. Patients completed questionnaires before and after surgery that included a single item on satisfaction selleck screening library with their health (based on the International Prostate Symptom Score [IPSS] Bother Question), disease-specific measures of symptoms/disability (Oxford Hip and Knee Scores, Aberdeen Varicose Vein Questionnaire), generic measures of symptoms/disability and of quality of life (QoL) (EQ [EuroQoL]-5D index), and single transitional items. Nonparametric
Spearman’s correlations explored relationships between measures.
Results: Before surgery, in all conditions, satisfaction was associated with other dimensions (P<0.05): generic QoL (r = 0.5-0.7), disease-specific symptoms/disability (r = 0.6-0.8), and generic symptoms/disability (r = 0.2-0.4). Significant improvements in satisfaction after surgery correlated strongly with change in disease-specific symptoms/disability (r = 0:6 for major operations and r = 0.35 for minor surgery) and with single transitional items (r = 0.4-0.6) but less so with change in generic QoL (0.3-0.4) and generic symptoms/disability (0.1-0.2).
Conclusion: Inclusion of a single item on satisfaction provides additional insight into the impact of surgery. (C) 2012 Elsevier Inc. All rights reserved.
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