The main goal of this study was to examine potential synergistic activity in combinations of NAO and commercial antioxidants. The antioxidant activity was tested in several in vitro systems including fatty acid and fat oxidation and also in cancer cell lines. We used the unique optical live cell array (LCA) technology to monitor the generation
of reactive oxygen species (ROS) in single cells over time. NAO was combined with selected commercial antioxidants, and synergistic ERK pathway inhibitors activity that reduced ROS generation was found with three polyphenols – ferulic acid, caffeic acid, and epigallocatechin-3-gallate (EGCG). These findings demonstrate the importance of using antioxidant ‘cocktails’ which may enhance medical effects in many kinds of diseases, including cardiovascular diseases and cancer. (c) 2008 Elsevier Ltd. All rights reserved.”
“A PXD101 theoretical analysis has been carried out to study the efficient microwave processing of discrete food sample ceramic composite attached with ceramic (Al(2)O(3) and SiC) plates. Continuous food sample with a specific thickness corresponding to smaller power absorption is replaced by two discrete samples and processed with ceramic composite. The effective power and temperature distribution are found to be function of discrete food
sample ratios, type of microwave incidence and ceramic layer thickness. The effect of ceramic material on various discrete sample ratios have been studied via effective average power vs. thickness of ceramic (Al(2)O(3) or SiC) intermediate for one side and both sides microwave incidence. It is found that power absorption is enhanced significantly for beef sample due to specific thickness of ceramic composite corresponding to one side microwave incidence. The power enhancement is lesser and the temperature difference or thermal runaway is larger for bread samples as compared to beef samples. The enhancement of heat absorption is larger
for one side incidence as compared to both sides incidence with identical total intensity of microwave incidence. The role of discrete samples with ceramic composites is significant for highly lossy substances (beef) whereas the composites do not play significant role on optimal processing of low lossy substances (bread). (c) 2008 Elsevier Autophagy Compound Library ic50 Ltd. All rights reserved.”
“Background: Occasionally, a bone graft or comminuted fracture fragment is dropped on the operating-room floor and becomes contaminated. The purpose of this study was to determine an optimal method for sterilizing this bone with the minimum sacrifice of cell viability.
Methods: A set of discarded bone samples was taken from a series of twenty total knee arthroplasty operations. The bone samples were uniformly contaminated with use of a bacterial broth prepared from culture samples taken from the operating-room floor. The bone samples in each set underwent five different decontamination procedures.
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