These include the hepatitis B carrier state, chronic hepatitis C virus (HCV) infection, hereditary hemochromatosis, and cirrhosis of almost any cause [14]. While, development of HCC in patients with Wilson disease is extremely rare. In see more conclusion, a periodic follow up of Wilsons disease patients with periodic checkup of alfa-fetopritien level

and abdominal US is recommended in order to discover the HCC earlier and they can benefit from other modality of treatment of HCC i.e. surgical resection, Radiofrequency ablation, Transarterial chemoembolization, or other modality that might be indicated. Possible consideration of inclusion in a transplant program can benefit the patients in some cases. Conclusion: In conclusion, a periodic follow up of Wilsons

disease patients selleck chemicals with periodic checkup of alfa-fetopritien level and abdominal US is recommended in order to discover the HCC earlier and they can benefit from other modality of treatment of HCC i.e. surgical resection, Radiofrequency ablation, Transarterial chemoembolization, or other modality that might be indicated. Possible consideration of inclusion in a transplant program can benefit the patients in some cases. Key Word(s): 1. Wilson’s disease; 2. HCC; 3. follow-up; Presenting Author: ALVIN BRIANCO VELASCO Corresponding Author: ALVIN BRIANCO VELASCO Affiliations: UST hospital Objective: Hepatocellular carcinoma (HCC) may occur in patients with negative serum HBsAg but with evidence of exposure to the hepatitis B virus (HBV). However, factors that may predispose these patients to develop HCC have not been well elucidated. The objective is to identify factors associated with HCC in patients previously exposed to HBV. Methods: From January 2005 to September 2011, patients with negative serum HBsAg but with HBV exposure, defined as the presence of either: isolated anti-HBc; anti-HBs with anti-HBc/anti-HBe; or anti-HBs with no HBV vaccination history; were grouped into those with HCC (group1) and without

medchemexpress (group2). Demographics and laboratory characteristics were compared. Results: A total of 91 and 80 patients were included in group1 and group2, respectively. Expectedly, group1 was older (65.31 + 10.99 vs. 52.06 + 13.03; p = <0.001), more likely to be male (79% vs. 53%; p = <0.001), diabetic (34.5% vs 19%; p = 0.035), cirrhotic (51.3% vs 20.3%; p = <0.001), jaundiced (17.5% vs 5.0%; p = 0.011) and have poorer liver function as exemplified by higher total bilirubin (2.22 + 3.93 vs 1.23 + 1.32; p = 0.03) as compared to group2. There was no difference in alcohol intake (p = 0.199). Interestingly, the likelihood of having a relative with HBV was higher in group2(group1 = 9% vs. group2 = 22.8%; p = 0.021), which may have resulted in group2 patients seeking medical consult earlier, leading to a diagnosis being made before complications from HBV exposure set in. Only age (OR = 1.068; 95%CI-1.019–1.119) and creatinine (OR = 3.567; 95%CI-1.020–12.

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