This paper aims to investigate associations between exposure to ambient wood smoke, traffic-related air pollution and current asthma/asthma severity in middle age, and whether any associations are modified by atopic
status.
MethodsUsing data from the Tasmanian Longitudinal Health Study, associations between ambient wood smoke and two indices of traffic-related air pollution (frequency of heavy vehicles near the home and frequency of intense traffic noise) and current asthma/asthma severity were investigated. Unconditional logistic regression to examine current asthma and ordinal logistic regression to examine I-BET-762 clinical trial asthma severity was used.
ResultsFor asthmatics, both exposure to ambient wood smoke (odds ratio 1.11; 95% confidence interval 1.02-1.20) and being frequently exposed to heavy vehicles (odds ratio 1.80; 95% confidence interval 1.09-2.96) were associated with increased asthma severity. Neither association varied by atopic status.
ConclusionsIn middle-aged adults, ambient wood smoke and traffic pollution were associated with increased asthma
severity. These findings suggest that avoiding or limiting exposure to traffic pollution and wood smoke may help to reduce asthma. Future studies to replicate this finding are recommended and should examine specific biological mechanisms for this effect.”
“Objective: The objective of this study was to investigate the relationship between neuropsychological functioning and the ability to work in cancer survivors.
Methods: Torin 1 in vivo The study involved a consecutive cohort of 45 patients who had received a primary diagnosis of
cancer, were gainfully employed at baseline, and had been treated with curative intent. Twelve months after the first day of sick leave, they underwent a neuropsychological assessment that included executive function and verbal memory tests. Other clinical, person-related, and work-related factors were also assessed by questionnaire at this time. Ability to work was measured as perceived workability (0-10) and work status at 12 MLN8237 months of sick leave.
Results: Fifteen participants (33%,) showed neuropsychological impairments covering various domains. The mean workability score of cancer survivors with neuropsychological impairment was 4.9, whereas those without impairments had a mean score of 6.0 (raw beta = -0.19: 95% CI = -2.9 to 0.7; adjusted beta = -0.15; 95% CI = -2.5 to 0.8). More cancer survivors with neuropsychological impairments (7/15, 47%) than without (9/30, 30%) bad not yet returned to work (raw OR 0.5: 95% CI: 0.1-1.8; adjusted OR 0.5; 95% CI: 0.1-2.1).
Conclusions: To date, this is the largest study to assess neuropsychological functioning objectively in combination with perceived workability and work status.
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