Those who knew that a family history
increased risk due to discussions with a doctor were excluded from the regression analysis. This study was approved by the University of Newcastle (2008-0047) and Cancer Council Victoria (0810) ethics committee, and all participants provided written consent. Of the 2928 eligible ICs sent a letter by the registry, 1084 (37%) gave consent for their details to be given to the research team and 753 (69%) completed the baseline interview. Of these, 649 (86%) had FDRs and agreed to them being invited to participate in the study. This led to 2376 FDRs being sent an invitation letter and 904 (38%) consenting to complete the interview to assess trial eligibility. Consenting FDRs were more likely to be female (X2(1) = 34.0, p < 0.001) compared with FDRs who were sent the invitation letter but did not consent to the study. There was no difference in consent rate depending on
learn more family risk status and relationship to the IC (Carey et al., unpublished). Forty consenting FDRs were ineligible to participate and 819 completed the baseline interview. These FDRs belonged to 416 families with an average of 1.91 members (SD = 1.13) per family. The demographics of the FDR participants are shown in Table 1. Overall 36% (295/819) of participants recalled ever being asked about their family history of bowel cancer by a health professional. Most discussions about family history of bowel cancer were with a GP (84%) while 20% involved
a cancer specialist, 1.4% a genetic counsellor and 4.4% another sort of medical professional. Most of the PTK6 discussions took place in the past 12 months (69%). However, 16% APO866 ic50 were over 5 years ago. On average FDRs who have discussed family history with a health professional have done so on 2.34 occasions (SD = 2.18). Just under half the sample reported that they had known that family history increases risk of bowel cancer for longer than 5 years (46%) while 43% became aware in the past year. The length of time that participants knew this fact was dependent on how they knew (Table 2; X2(3df) = 308, p < 0.001). Those who found out after a family member was diagnosed (62%) or from the letter sent by the Cancer Council (3%) were more likely to have found out recently compared to those who knew from information obtained from the media (18%), discussions with their doctor (3%), from their own education (10%) or talking with friends and relatives (4%). The results of the multiple logistic regression modelling are presented in Table 3. The factors associated with being asked by a health professional about family history of bowel cancer are: aged 50–60 compared to under 50, having a university education, being in the potentially high risk category, being very worried about getting bowel cancer and knowing that family history increases risk through discussions with family, friends or their own education.
No related posts.