“
“We report femtosecond transient reflectivity measurements of as-grown and iron-doped GaxIn1-xAs. A hybrid vertical Bridgman and gradient freezing directional solidification process was employed for the growth of high quality Ga0.69In0.31As:Fe crystals with the uniform impurity doping concentration necessary for high resistivity (1.6×10(7) cm) and high mobility [(2-3)x10(3) cm(2)/V s] material. Carrier lifetimes range from similar to 62 fs for as-grown Ga0.09In0.91As to similar to 306 fs for Ga0.69In0.31As:Fe. The high carrier mobility along with high resistivity and subpicosecond carrier lifetimes make Ga0.69In0.31As:Fe an excellent candidate for photoconducting
antenna based terahertz emitters.”
“Background-Inflammatory FK228 in vitro cytokine interleukin-6 (IL-6), a possible risk factor for coronary heart disease, has an estimated heritability of >60%, but to date few genetic AZD1480 manufacturer variants influencing IL-6 levels are known.
Methods and Results-We used the ITMAT-Broad-Care (IBC) HumanCVD disease BeadChip in
the Whitehall II study (N=4911) and British Women’s Heart and Health Study (N=3445) to identify single-nucleotide polymorphisms associated with circulating IL-6 levels. Twenty-two single-nucleotide polymorphisms from 7 loci (IL6R/TDRD10, HLA-DRB1, BUD13, SEZ6L, IL1RN, TRIB3, and ABO) were associated with IL-6 (P<10(-5)), although none were associated with the IL6 gene itself. With the exception of TRIB3, all loci have been previously reported in genome-wide association studies for autoimmune and cardiovascular diseases. Fourteen single-nucleotide polymorphisms in the IL6R region in high-linkage disequilibrium (r(2)>0.9) with a nonsynonymous variant, rs2228145, were also associated with IL-6 and
C-reactive protein concentration (P<10(-5)). An IL-6-specific weighted allele score explained 2% of the variance of log IL-6 levels (P=2.4410(-22)) in Whitehall II and 1% (P=1.910(-8)) in British Women’s Heart and Health Studies.
Conclusions-Multiple common genetic variants of modest effect influence IL-6 concentration. Several loci contain single-nucleotide polymorphisms, exhibiting overlapping associations 10058-F4 solubility dmso with autoimmune and cardiovascular disorders and other circulating biomarkers. Genetic variants associated with IL-6 provide important tools for probing the causal relevance of IL-6 signaling in a range of cardiometabolic diseases. (Circ Cardiovasc Genet. 2013;6:163-170.)”
“We made a cytogenetic study of Rineloricaria pentamaculata from the Taua Stream, in the Pirapo River sub-basin in Parana State, Brazil, focused on the occurrence and origins of the B chromosomes. The diploid number varied from 2n = 56 to 2n = 59, due to the presence of 0 to 3 B microchromosomes of the acrocentric type, which were observed in 92.3% of the specimens (N = 12).
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