White/non-Hispanics and Hispanics had a higher prevalence of current HCV infection (14% and 15%, respectively) compared with black/non-Hispanics (7%) (odds ratio [OR]=2, 95% confidence interval [CI]=1.47-2.93 and OR=2, 95% CI=1.9-2.9). Ever having
injected drugs was the strongest risk factor for HCV infection (OR=20.6, CI=16.4-26.0). Of the participants with current infection, 85% attended their first medical appointment; as of April 2014, over 50% remained in care. Discussion: The community-based testing model successfully identified a large number of persons with HCV infection and linked a high proportion to care. The high prevalence of HCV infection among baby boomers supports the NY Testing Law and CDC recommendations. Expanding this this website model to more settings with high-risk populations will aid in successfully identifying and linking HCV positive
individuals into care. Disclosures: Eric J. Rude – Grant/Research Support: Vertex, Merck, Bristol Myers IWR-1 in vivo Squibb, Orasure, Janssen, Gilead, Kadmon, Boehringer-Ingelheim, Abbott, Genentech The following people have nothing to disclose: Mary Ford, Ashly Jordan, Nirah Johnson, Holly Hagan, Fabienne Laraque, Jay K. Varma Background: The hepatitis C virus (HCV) first identified in 1989 is a highly infectious blood borne virus that has spread extensively globally, especially among people who inject drugs (PWID). The current study uses pooled biological and behavioral data from 8 individual prospective studies of PWID to describe HCV incidence over time (1985-2011), across locales (U.S., Canada, the Netherlands, and Australia). Methods: We used life table methods to estimate the incidence of HCV infection within the first two years of follow-up by locale, and estimated rate ratios to compare infection rates between learn more locales. Results: Of 5,248 participants, 2,891 (55%) tested HCV negative at enrollment; of these, 2,197 (42%) were followed prospectively for a median of 1.2 years (Interquartile range [IQR]: 0.5, 2.6 years); median age at study entry was 25 (IQR, 21, 28), the majority were white (69%) and male (64%). The drug injected
most often included heroin (50%), [meth]amphetamines (18%), cocaine (12%), and other opioids (7%) and varied by locale. During 5,259 person-years observation (pyo) of follow-up, 673 became infected for an estimated overall incidence of 12.8/ 100 pyo (95% CI: 12, 14). HCV incidence was highest within the first 5 years of study observation (14.0/pyo; 95% CI 12, 15). Historical trends in HCV infection rates (≤2 years follow-up) decreased for participants in the Dutch and Australian cohorts, increased for Canadian cohorts, and remained steady for American cohorts across 1985-2011 (table 1). Incidence (≤2 years follow-up) was highest among cohort participants in the U.S. (27.7 / pyo; 95% CI 24, 31), followed by Canada and Australia at 23.6/pyo (95% CI 18, 29) and 12.
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