6. Conclusions Physiological adaptations to physical exercises lead to blood volume redistribution favoring the working muscle supply with oxygen and energy-yielding substrate as well as the skin for heating dissipation as sweat. Strenuous exercise and/or hot-humid environments precipitate body dehydration, which may induce core hyperthermia, Pevonedistat muscle glycogen depletion, gastric emptying delay, gut underperfusion (and ischemia) followed by endotoxemia or anaphylaxis. Rapid fluid delivery from fluids intake is the goal of oral rehydration solutions and sports drinks, that provide the addition of sodium and carbohydrates to assist the intestinal
absorption of water and muscle-glycogen replenishment, respectively. However, sometimes, fluid delivery and carbohydrate delivery are difficult to reconcile as carbohydrate-rich beverages decrease fluid delivery to the gut, thus delaying water absorption and accentuating gut underperfusion. It is necessary to inform athletes about potential dangers of drinking too much water, advise them to refrain from using hypertonic fluid
replacements. Nutritional Recommendations During intense exercise, is recommended an intake of 0,5 L/hour TGF-beta family of sports beverages. A CHO (<10%) and sodium beverage should be encouraged. To increase the CHO exogenous oxidation, glucose plus fructose should be consumed. References 1. Burini FHP, de Oliveira EP, Burini RC: Metabolic
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