For our animals, aggressive behavior was observed during

and after treatment and also during and after blood collection from the tails. These events may mimic provocative conditions that have often led to student unrests. Studies conducted earlier however showed that given acutely, over a few hours, no abnormal neurologic signs or behavior were notable in baboons [38]. This is in agreement with our findings where we noted no significant alteration in testosterone selleck inhibitor levels for the first week of supplementation. This means that it may requires chronic kerosene supplementation to see both increase in T levels in blood and the T mediated effects on behavior such as increased aggressive tendencies. The mechanism through which the kerosene results in the increase of T remains to be elucidated. Various studies have shown that ingestion or inhalation of kerosene could lead to various toxic effects [27], [39] and [40]. Reported clinical effects of accidental ingestion or suicide attempt are quite varied ranging from mild to fatal. The severities of the effects appear to be largely dependent on the quantity ingested, the age and interaction with drugs (such as metformin) that the victim might be using at the

time of ingestion [41] and [42]. The common effects include cough with difficulty in breathing, vomiting, fever, central nervous system involvement, severe lactic acidosis and acute renal failure, pyopneumothorax and deaths[41], [42] and [43]. It is important to note that effects reported on accidental ingestion or intended suicide crotamiton http://www.selleckchem.com/products/obeticholic-acid.html are acute effects occurring within a short period of time post ingestion and are usually due to ingestion of large quantities. We therefore postulated that chronic dietary kerosene supplementation albeit at lower doses than above (accidental or suicide attempt) may also be harmful to body tissues. We thus investigated the potential toxic effects of kerosene on the liver, kidney, blood and the brain, esophagus and

stomach lumen. It was notable from our findings that there was a uniform steady rate of increase in the body weights from all the three groups with no significant difference (P > 0.05) among the three groups. Regarding potential toxic effects to the liver, relative to the control group, kerosene supplementation showed little to no effects (Figs. A and B). The liver enzymes remained unchanged (ALT, P= 0.97 and P = 0.35, AST, P = 0.11 and P = 0.34 for low and high dose groups respectively. Similarly, kerosene supplementation did not have a significant effect on the serum total proteins. Although results depicted a decreasing trend, it did not reach statistical significance (low dose P = 0.064, high dose P = 0.068). Serum albumin levels showed a significant decrease of P = 0.

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