He was accepted as a resident in the Mayo Foundation and Graduate School at the University of Minnesota, MK-2206 clinical trial serving from 1957 to 1961, and he became board certified in Anatomic and Clinical Pathology. Dr. Titus earned a Ph.D., degree in pathology from the University of Minnesota, Mayo Graduate School of Medicine in 1962 (under the mentorship of Jesse E. Edwards, M.D.). He served as Associate Professor of Pathology and as a consultant in pathology at the Mayo Graduate School of Medicine from 1961 to 1972 and became a professor there in 1972. He was also coordinator of the Pathology
Training Programs from 1964 to 1972. In 1972, he was recruited to The Baylor College of Medicine in Houston, TX, to become the W.L. Moody, Jr., Professor and Chairman of the Department of Pathology, a position that he held until 1987. He served concurrently as Chief of the Pathology Service at The Methodist Hospital and Pathologist-In-Chief of the Harris County Hospital District. In 1987, upon the retirement of Dr. Jesse E. Edwards from the Registry of Cardiovascular Diseases United Hospital, St. Paul,
MN, which houses a collection of more than 20,000 heart specimens and 85,000 photographic slides, Dr. Titus was recruited as the second director. He also was a Professor of Pathology Selleck Bcl2 inhibitor on the University of Minnesota Medical School faculty. During his Electron transport chain time at the Registry, he continued to serve as Adjunct Professor at the Baylor College of Medicine. Although Dr. Titus retired in 2004, he continued to serve as senior consultant to the Jesse E. Edwards Registry of Cardiovascular Disease. Dr. Titus made many contributions to our discipline, its knowledge base, and the mentorship of its participants.
He fostered an early understanding of the normal AV conduction system, sudden cardiac death, the surgical anatomy of congenital heart disease. He published studies on how the AV conduction system was distorted in congenital heart disease and particularly in septal defects, and, in collaboration with cardiac surgical pioneers and other pathologists, he contributed to the development of the surgical and catheter-based repair of congenital heart disease and the pathological anatomy of both valvular heart disease and valve replacement by homograft and prosthetic valves. With pathologists, he collaborated on the earliest studies of the early diagnosis of myocardial infarction by the triphenyl tetrazolium chloride (TTC) macroscopic staining technique and the pathology of coronary artery bypass graft surgery. Dr. Titus was instrumental in the founding of the Society for Cardiovascular Pathology (SCVP) in 1985 and served on and as an enthusiastic and wise advisor to its Executive Council for many years. In 1993, Dr.
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