Our results show that efficient cholesterol extraction depends on the structural distribution of the CDs on the surface of the monolayer. With a suitably oriented dimer, cholesterol is extracted
spontaneously on a nanosecond time scale. Additional free energy calculations reveal that the CDs have a strong affinity to bind to the membrane surface, and, by doing so, destabilize the local packing of cholesterol molecules making their extraction favorable. Our results have implications for the interpretation of experimental measurements, and may help in the rational design of efficient CD based nano-carriers.”
“The spinning of poly(ethylene terephthalate) (PET) filaments in laboratory-scale Bcl-2 phosphorylation was studied. The objective was to study the effect of modified calcium silicate (CS) with vinyltriethoxysilane (VTES) on the melt spinning of PET fibers. The CS was modified with VTES (2% v/v) in diethyl ether at room temperature for 24 h. The modification of CS with VTES improved agglomeration of CS, hydrophobic, and heat-resistance properties. These properties were expected that modified CS could be used as the filler in melt spinning of PET. The incorporation of
modified CS in PET was spinnable. The addition of CS in PET improved its heat resistance. Also, the filler had an effect on the mechanical properties of polyester fibers. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Cells exposed to genotoxic stress, such as ionizing radiation and DNA damaging reagents, either arrest the cell cycle to repair the genome, or undergo apoptosis, depending on the extent of the DNA damage. DNA damage also has been implicated in various differentiation processes. It has been reported OICR-9429 mw that gamma-ray exposure or treatment with DNA-damaging agents could induce myogenic differentiation in Drosophila Schneider cells. However, the mechanism underlying this process has been poorly understood. In this study, exposure of Schneider cells to X-rays or energetic carbon ion beams caused increase of TUNEL-positive cells and conversion of round-shaped cells to elongated cells. Both upregulation of genes related to myogenesis and increase of myosin indicate that the radiation-induced Geneticin morphological
changes of Schneider cells were accompanied with myogenic differentiation. Because the intracellular ceramide was increased in Schneider cells after exposure to X-ray, we examined whether exogenous ceramide could mimic radiation-induced myogenic differentiation. Addition of membrane-permeable C(2)-ceramide to Schneider cells increased apoptosis and expression of myogenic genes. These results suggest that ceramide plays important roles in both apoptosis and the radiation-induced myogenic differentiation process.”
“The authors have investigated the chemical states at the interface of metal/perovskite oxides both with and without bipolar resistive switching (RS) behavior using photoemission spectroscopy and x-ray absorption spectroscopy. Al/Pr(0.7)Ca(0.3)MnO(3) (PCMO), Al/La(0.
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