Indeed it is expected that travelers will change some of their plans (destination, duration, or planned activities) while traveling, but it is not known to what extent differences between intended and actual travel plans will affect pre-travel advice. In a prospective study, we assessed the agreement buy UK-371804 between pre-travel plans (intended plans) and post-travel history (real or actual trip). In case of disagreement we assessed the expected effect on the recommendation for travel-related vaccines and malaria prevention. During pre-travel consultation, we prospectively recruited all consenting adults (>16 years old) who
had not planned an organized tour. Only one person per couple was included. The study took place at the Travel Clinic, Department of Ambulatory Care and Community Medicine, University of Lausanne, Switzerland
from February 2008 up to February 2009. Participants gave informed consent and were asked to complete a small questionnaire for demographics, telephone number(s), and email address. Pre- and and post-travel information included questions on destination, itineraries, departure and return dates, access to bottled water, plans to bicycle ride, stays in a rural zone or with local people, and close contact with animals. These variables were chosen because they determined travel-related disease risks and specific recommendations for vaccines or malaria prevention. DCLK1 The traveler’s access to bottled water was a measure to find more be associated with typhoid vaccine recommendations; plans to bicycle ride or to have close contact with animals was associated with rabies vaccine; and stays in rural zones was associated with Japanese encephalitis or meningitis vaccine
(Asia and sub-Saharan Africa, respectively). Pre-travel information was extracted from travel clinic electronic files, where this information is systematically entered to decide on the administration of vaccines and recommendations for malaria prevention. Post-travel information included the same questions as those asked during the pre-travel interview, and was collected using phone calls or email (up to 1 month after return). Outcomes measures included: (1) agreement between pre- and post-travel history, and (2) changes in pre-travel recommendations that would have been expected to occur based on the actual trip (ie, the actual destinations and travel-related activities). In Switzerland, pre-travel health counseling is based on recommendations from the Swiss Commission of Travel Medicine and published by the Swiss Federal Office for Public Health.