Fifteen LRYGB studies with a total

of 588 patients and ei

Fifteen LRYGB studies with a total

of 588 patients and eight LSG studies with 286 patients were included. The reason for revision was insufficient weight loss or weight regain in 62.2 and 63.9 % in LRYGB and LSG patients. Short-term complications occurred in 8.5 and 15.7 % and long-term complications in 8.9 and 2.5 %. Reoperation was performed in 6.5 and 3.5 %. Revision to LRYGB or LSG after (L)AGB is feasible and relatively safe. Complication rate is higher than in primary procedures.”
“Leptospirosis find more is a zoonosis of worldwide occurrence caused by the spirochete Leptospira interrogans. It is an acute feverish disease with a broad clinical spectrum and follows a characteristic biphasic course. Bilateral facial palsy is a rare clinical condition and the differential diagnosis of its causes is extensive. The objective of this exploratory study, presented as a case report, is to describe the occurrence of bilateral facial palsy as an unusual

manifestation of leptospirosis. This suggestion should not be overlooked when analyzing the causes for bilateral facial palsy, and should be considered with other possible differential diagnoses, some of which are potentially fatal.”
“OBJECTIVE: AO/OTA 31-A3 intertrochanteric femoral fractures have completely different fracture Selleckchem IACS-10759 line directions and biomechanical characteristics compared with other types of intertrochanteric fractures. The choice of the fixation method has been a focus of dispute among orthopedic trauma surgeons. The purpose of this study was to review the outcomes Selleckchem Vadimezan of these fractures treated with a percutaneous compression plate at our institute.

METHOD: Seventeen patients with AO/OTA 31-A3 intertrochanteric femoral fractures were treated

with a percutaneous compression plate at our institute from January 2010 to December 2011. The clinical data and imaging results were retrospectively analyzed.

RESULTS: The medical complication of popliteal vein thrombosis occurred in one patient. Sixteen patients were followed up for 12 to 21 months. Two patients had malunion and mild pain. Fracture collapse occurred in two patients, with one having head penetration. These two patients had moderate pain. There were no occurrences of nonunion or reoperation. The mean Harris hip score obtained during the last follow-up was 84.1 (61-97). Patients with a poor quality of reduction were more likely to have pain results (p= 0.001). A trend existed toward the presence of a poor quality of reduction (p= 0.05) in patients with a collapse of fracture. Patients with poor preoperative mobility were more likely to have a lower Harris hip score (p= 0.000).

CONCLUSION: The percutaneous compression plate is an alternative device for the treatment of AO/OTA 31-A3 intertrochanteric femoral fractures. Good fracture reduction and an ideal placement position of the neck screw are important in the success of the device.

21985 The authors have no funding, financial relationships, or co

21985 The authors have no funding, financial relationships, or conflicts of interest to disclose.”
“Background: Heart failure (HF) is associated with an overall stroke rate that is too low to justify anticoagulation in all patients. This study was conducted to determine if vascular risk factors can identify a subgroup of individuals with heart failure PF-562271 cell line with a stroke rate high enough to warrant anticoagulation. Methods:

The REGARDS study is a population-based cohort of US adults aged >= 45 years. Participants are contacted every 6 months by telephone for self-or proxy-reported stroke and medical records are retrieved and adjudicated by physicians. Participants were characterized into 3 groups: HF without atrial fibrillation (AF), AF with or without HF, and neither HF nor AF. Cardiovascular risk factors at baseline were compared between participants with and without incident stroke in HF and AF. Stroke incidence was assessed in risk factor subgroups in HF participants. Results: Of the 30,239 participants, those with missing/anomalous data were excluded. Of the remaining 28,832, 1360 (5%) had HF without AF, 2528 (9%) had AF, and 24,944 (86%) had neither. Previous

stroke/transient ischemic attack (TIA; P = .0004), diabetes mellitus (DM; P = .03), and higher systolic blood pressure (P = .046) were associated with increased stroke SRT2104 order risk in participants with HF without AF. In participants with HF without AF, stroke incidence was highest in those with previous stroke/TIA and DM (2.4 [1.1, 4.0] per

100 person-years). Conclusions: The combination of previous stroke/TIA and DM increases the incidence of stroke in participants with HF without AF. No analyzed subgroup had a stroke rate high enough to make it likely that the benefits of warfarin would outweigh the risks.”
“Aim:

We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method.

Material and Methods:

Thirty BI 2536 nmr four preeclamptic and 27 normotensive pregnant women were enrolled in this prospective controlled study. Subjects were selected from women attending the Obstetrics and Gynecology Department of Gaziantep University. TAS, TOS, OSI were measured from placental, maternal and cord blood samples using a novel automated method. Statistical analyses were performed with SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA).

Results:

The TAS level of the placenta was evaluated as significantly lower (P < 0.001) in preeclamptic women compared to normotensive women. In preeclamptic pregnancies, while the placental TAS level was not correlated with placental TOS level, the TAS levels of maternal plasma (P < 0.001; r = 0.584) and cord plasma (P < 0.005; r = 0.529) were significantly correlated with the TOS level of the placenta.

The clinical and hematologic findings resolved with treatment of

The clinical and hematologic findings resolved with treatment of the infection. Brucella infection should be suspected in liver transplanted recipients with fever of unknown origin, especially in a recipient who has lived in an endemic area. Brucella also should be GF120918 supplier considered as a possible diagnosis in patients with pancytopenia.”
“Purpose of reviewIt is easy to forget the contribution of electromyography (EMG) to the investigation of paediatric peripheral neuromuscular disease, and this review highlights its continued importance.Recent findingsThe discovery that Brown-Vialetto-van Leare disease, when associated with disorder of riboflavin metabolism,

may be treatable has raised awareness of the importance of EMG for its early detection. Unexpected discovery of motor neuronopathy, which may be useful for the definition LCL161 mouse of the phenotype of several conditions,

now has an added significance. The investigation of disorders of peripheral nerve cannot proceed without nerve conduction studies but particular interest has been shown in its role in the management of obstetric brachial plexus palsy, with investigation within 1 month now recommended. The key role of neurophysiology in identifying abnormalities of the neuromuscular junction, and therefore leading investigators to a diagnosis of myasthenia, is once again highlighted. EMG in muscle disease continues to have a role, particularly when identifying myotonia.SummaryPaediatric EMG, while a daunting technical challenge to some practitioners, remains a valuable investigative tool for the specialists in paediatric neuromuscular

disorders and will continue to deliver important diagnostic information, often as quickly and accurately as other more recent innovations.”
“The effect of dehydroepiandrosterone (DHEA) supplementation on cycle outcome was assessed in patients with poor ovarian response. In total, 19 poor responder Angiogenesis inhibitor patients who were scheduled to undergo a second intracytoplasmic sperm injection (ICSI)/embryo transfer cycle were enrolled and first ICSI/embryo transfer cycles were taken as the control group. All subjects were given DHEA supplementation (25 me, t.i.d.) for at least 3 months prior to their second ICSI/embryo transfer cycle. In both cycles a fixed dose of rFSH (300 IU/day) and human menopausal gonadotrophin (HMG) (75 or 150 IU/day) along with a flexible gonadotrophin-releasing hormone (GnRH) antagonist protocol were administered. A favourable decrease was noted in mean day 3 serum oestradiol concentrations after DHEA Supplementation (75.14 +/- 28.93 versus 43.07 +/- 11.77; P < 0.01). Increased number of >17 mm follicles (3 +/- 0.7 versus 1.9 +/- 1.3; P < 0.05), MII oocytes (4 +/- 1.8 versus 2.1 +/- 1.8; P < 0.05), top quality day 2 (2.2 +/- 0.8 versus 1.3 +/- 1.1: P < 0.05) and day 3 embryos (1.9 +/- 0.8 versus 0.7 +/- 0.6; P < 0.05) were achieved in DHEA-supplemented cycles.

58) No complication was attributable to palpation technique

58). No complication was attributable to palpation technique.

Conclusion: Suprasternal palpation shows promise

as a simple, safe, and teachable method of confirming ETT position in neonates.”
“To evaluate the prevalence and risk factors of urge urinary incontinence (UUI) in Chinese adult women.

A cross-sectional study using the multistaged random sampling method. Twenty thousand Chinese women aged a parts per thousand yen20 years were interviewed.

Of the women aged 20-99 years, the prevalence of UUI was 2.6%, Saracatinib price which increased with age. Age, waist circumstance, constipation, chronic pelvic pain, history of gynecological diseases, and menopausal status were independent risk factors of UUI. Women aged 60 or above were 2.329 times more likely to suffer UUI as compared to women aged 20-40. Women in perimenopausal or postmenopausal status were, respectively, 1.766 or 2.285 times more likely to suffer UUI as compared to women in normal menstruation. However, parity and mode of delivery were not risk factors.

The prevalence of UUI is 2.6% among Chinese adult women. Age is a major independent risk Selleckchem GNS-1480 factor of UUI.”
“PURPOSE: To compare the anterior and posterior elevation measurements

above the best-fit sphere (BFS) between the Galilei (dual-Scheimpflug) and Pentacam (single-Scheimpflug) systems in candidates for refractive surgery.

SETTING: Poostchi Ophthalmology Research Center, Shiraz, Iran.

METHODS: In this prospective study, both eyes of consecutive patients were examined with the 2 imaging systems. The anterior and posterior BFS and the central and maximum elevation measurements in each of 4 quadrants were compared between the dual-Scheimpflug system and the single-Scheimpflug system. Bland-Altman plots were used to evaluate the agreement in the measurements between the imaging

systems.

RESULTS: The study comprised 31 patients (62 eyes). The mean radius of the anterior BFS measurement was 7.72 mm +/- 0.21 (SD) with the AZD4547 dual-Scheimpflug system and 7.83 +/- 0.21 mm with the single-Scheimpflug system. The mean radius of the posterior BFS was 6.37 +/- 0.18 mm and 6.47 +/- 0.19 mm, respectively. On the anterior and posterior elevation maps, the single-Scheimpflug system led to statistically significantly higher measurements than the dual-Scheimpflug system in the central, inferior, and temporal elevations (P<.001). Bland-Altman plots showed more agreement between the systems in anterior elevation measurements than in posterior elevation measurements.

CONCLUSION: In refractive surgery candidates with healthy eyes, the elevation map measurements with the single-Scheimpflug system were significantly different from those with the dual-Scheimpflug system in most aspects and therefore may lead to misinterpretation of clinical data that could alter clinical decisions if the 2 imaging systems are considered interchangeable.

As hGDH2 functions more efficiently under acidotic conditions wit

As hGDH2 functions more efficiently under acidotic conditions without the operation of the GTP energy switch, its presence in the kidney may increase the efficacy of the organ to maintain acid base equilibrium.”
“An experiment was performed for the observation of H emission induced in a cooled laser-induced atmospheric pressure gas plasma of He atoms in their metastable excited state. The strong H emission detected clearly established, to the exclusion of other well known major excitation processes, the exclusive contribution of the He-induced excitation (HIE) mechanism. The process is suggested to take place by means of energy transfer from

the excited He atoms to the H atoms via Penning collision induced ionization involving electron exchange. The result further shows that this website Z-IETD-FMK this mechanism may also work for elements other than H and thereby strongly suggests the use of ambient He gas to broaden and complement the applications of standard laser-induced breakdown spectroscopy. (C) 2011 American Institute of Physics. [doi:10.1063/1.3592351]“
“Office hysteroscopy is an excellent method of identifying and treating intracavitary uterine lesions.

It has become easy to learn and perform; as an aid of modern technological applications, it is safe, accurate, provides immediate results under direct visualisation, and offers the additional benefit of histological confirmation and the discomfort of patients is minimal. We

applied an extended literature search to explore the special features and details of the technique itself, as it evolved since it first appeared 30 years back. Our initial goal was to examine potential changes/improvements of the modality, in terms of the instrumentation used and the technique itself, the indications of use, its incorporation in daily practice, and patients’ and GSK2245840 supplier clinicians’ acceptability.”
“This article reviews evidence in support of the hypothesis that impaired activation of the extracellular signal-regulated kinases (ERK1/2) contributes to the disruptions in neurodevelopment associated with zinc deficiency. These kinases are implicated in major events of brain development, including proliferation of progenitor cells, neuronal migration, differentiation, and apoptotic cell death. In humans, mutations in ERK1/2 genes have been associated with neuro-cardio-facial-cutaneous syndromes. ERK1/2 deficits in mice have revealed impaired neurogenesis, altered cellularity, and behavioral abnormalities. Zinc is an important modulator of ERK1/2 signaling. Conditions of both zinc deficiency and excess affect ERK1/2 phosphorylation in fetal and adult brains. Hypophosphorylation of ERK1/2, associated with decreased zinc availability in cell cultures, is accompanied by decreased proliferation and an arrest of the cell cycle at the G0/G1 phase.

81, 95% confidence interval 0 71-4 60) and the other HPV types gr

81, 95% confidence interval 0.71-4.60) and the other HPV types group (hazard ratio 2.09, 95% confidence interval 0.73-5.96), whereas it was lower in the HPV 58 single positive group (hazard ratio 0.53, 95% confidence interval 0.11-2.56), but this was not statistically significant (P = 0.43). All results remained statistically non-significant after adjustment for age and tumour stage with multivariate Cox regression. No apparent differences were observed in the survival rates among the four groups with regard to the treatment protocols.

Conclusion: No effect was seen

of either treatment protocols or HPV type on survival, except for a slightly high survival in HPV 58 single-infected patients, which was statistically non-significant. Shah, W. et al. (2009). PF-562271 datasheet Clinical Oncology 21, 768-774 (C) 2009 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.”
“The conduction process during degradation, promoted by the application of fixed dc bias voltage at different temperatures (thermal steady states) and current pulses 8/20 mu s on ZnO

and SnO2-based varistors, was studied comparatively in the present work. The electrical properties of the varistor systems were highly damaged after degradation with current pulse PD173074 8/20 mu s. Variations on the potential barrier height and donor concentration were calculated by fitting the experimental data from impedance spectroscopy measurements assuming

the formation of Schottky barriers at the grain boundaries and electrical conduction to occur due to tunneling and thermionic emission. (C) 2010 American Institute of Physics. [doi:10.1063/1.3490208]“
“The aim of this pilot study was to demonstrate physiological movements of the muscular walls surrounding the abdominal cavity during breathing and coughing in healthy nulliparous women by means of real-time dynamic magnetic resonance imaging (MRI).

Eight volunteers underwent MRI measurements in a 1.5-T whole body MR-scanner. Coronal and sagittal slices were acquired simultaneously to assess respiratory-related cranio-caudal BGJ398 mouse movement of diaphragm and pelvic floor (PF) and concomitant changes in horizontal abdominal diameter.

Respective mean amplitudes of cranio-caudal movement of the right and left diaphragmatic cupolae were 15 +/- 6 and 9 +/- 7 mm during quiet breathing; 32 +/- 15 and 28 +/- 16 mm during forceful breathing; and 32 +/- 13 and 28 +/- 7 mm during coughing. Both diaphragm and PF moved caudally during inspiration and cranially during expiration. Abdominal diameter decreased in all eight women consistently during the expiration phase of breathing, and in five women during coughing.

In healthy women, real-time dynamic MRI demonstrates parallel cranio-caudal movement of the diaphragm and the PF during breathing and coughing and synchronous changes in abdominal wall diameter.

In the current study,

the incidence and severity of IT gr

In the current study,

the incidence and severity of IT granuloma formation was assessed for the MedStream Programmable Infusion and SynchroMed II Infusion pumps when delivering saline, baclofen, or morphine at varying concentrations and daily doses.

Design. LY2157299 datasheet Randomized study with six groups: 1) MedStream with 0.9% saline; 2) SynchroMed II with 0.9% saline; 3) MedStream with morphine sulfate; 4) SynchroMed II with morphine sulfate; 5) MedStream with baclofen; or 6) SynchroMed II with baclofen. The groups receiving morphine received either low or high concentrations ( 6 or 12.5 mg/mL) delivered in rates resulting in low to high ( 1.25-12 mg/day) daily doses. Animals receiving baclofen began at low dose/low concentration and underwent stepwise increases in concentration and dose to a maximum of 2 mg/mL/day. Animals receiving saline received a constant flow rate through either a silicone or a polyurethane IT catheter.

Setting. The study was set as in vivo laboratory experiment.

Subjects. 52 ICG-001 purchase ( 21-32 kg) canines.

Interventions. Delivering IT saline, baclofen, or morphine through SynchroMed II and MedStream

Programmable Infusion pumps

Outcome Measures. The incidence and severity of IT catheter tip granuloma formation was assessed with paraffin-embedded spinal cord sections by a pathologist without knowledge of treatment and compared between drug type, drug concentration, daily dose, and pump type.

Results. Granuloma formation occurred only in animals receiving morphine, with

zero incidence in baclofen or saline infusion, regardless of catheter type. Granuloma incidence increased with increasing morphine concentration or daily dose ( one [ 12.5%] low dose/low concentration, click here 3 [ 37.5%] low dose/high concentrations, 4 [ 50%] high dose/low concentration, and 7 [ 100%] high dose/high concentration). A granulomatous response to morphine was observed in 10 ( 63%) animals with SynchroMed II pumps and 5 ( 33%) animals with MedStream pumps, P = 0.156.

Conclusions. In this in vivo canine model of IT drug delivery, catheter tip granuloma formation was associated with higher concentrations and daily doses of morphine infusion while none were seen with baclofen or saline, and was not associated with catheter type. For both pumps, granulomas were only produced in the presence of morphine infusion. These results suggest that the MedStream Programmable Infusion System has a granuloma safety profile at least equivalent to that of the SynchroMed II pump.”
“Background and objectiveDespite problems associated with assessing the clinical effect and side effects of nebulized corticosteroids, little is known of the amount of drug that is inhaled by children with asthma or how this is affected by different drug formulations.

Postoperative follow-up of patients operated on with

this

Postoperative follow-up of patients operated on with

this modified technique indicates that the technique is feasible and safe, with no apparent selleckchem damage to the ovary. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Objective: There is growing evidence on the usefulness of biomarkers in the early detection of preterm infants at risk for brain damage. However, among different tools Activin A, S100B protein and adrenomedullin assessment offer the possibility to investigate brain/multiorgan function and development. This could be especially useful in perinatal medicine that requires even more non-invasive techniques in order to fulfill the minimal handling in diagnostic and therapeutic strategy performance. Materials and methods: The concept of Unconventional Biological Fluid (UBF: urine and saliva) is becoming even stronger and regards the assessment in non-invasive biological fluids of biochemical markers involved in the cascade of events leading to brain damage. Results: Activin A, S100B protein

Alisertib cell line and adrenomedullin in UBF were increased in preterm newborns developing brain damage and/or ominous outcome. Conclusions: The present manuscript offers an update on the usefulness of Activin A, S100B protein an adrenomedullin in UBF as brain damage markers. The findings open a new cue on the use of these markers in daily neonatal intensive care unit (NICU) activities.”
“Objectives:

To review the current status of lupus registries, highlight the importance and evolution of registries in clinical Fer-1 supplier lupus research, discuss substantial advances in the understanding of lupus through the use of registries, and discuss the future role of registries in terms of opportunities and challenges.

Methods: The literature reviewed originated from the PubMed database and was limited to adult disease in articles published before June 01, 2008. Keywords used in the PubMed search included the following terms: systemic lupus erythematosus, registry, cohort, and database. All articles were sorted and analyzed according to a template devised by the authors describing the different types of registries.

Results: The most important features of a lupus registry are that they contain a large number of subjects and reflect a relatively real world environment for lupus patients. Data obtained from the lupus registries are essential for planning, designing, and conducting clinical lupus studies, especially those difficult, inappropriate, or even unethical to study in randomized controlled trials. Up to now, some well-conducted registries have received recognition for their contributions to lupus research through their focus on different goals: epidemiology, genetics, ethnic diversity, clinical features, or outcomes.


“Background: A helmet mandatory for people younger than 16


“Background: A helmet mandatory for people younger than 16 years was implemented in most Austrian provinces in the winter season 2009/2010. The objective of this study was to evaluate the impact of a ski helmet mandatory on age-dependent helmet use.

Methods: We compared helmet use in people aged 15 years or less and older than 15 years of Austrian provinces with and without helmet mandatory between the 2008/2009 (n = 16,342) and 2009/2010 (n = 32,011) winter seasons.

Results:

Helmet use in people aged 15 years or less in the 2009/2010 season increased by 16.2% in provinces with helmet mandatory and decreased by 2.1% in provinces AZD9291 Protein Tyrosine Kinase inhibitor without helmet mandatory (all p < 0.001), respectively. However, provinces with and without helmet mandatory did not differ regarding mean helmet use in people aged 15

years or less (92.2% vs. 92.8%, p = 0.506) in the 2009/2010 season. Helmet use in HDAC inhibitor review people older than 15 years in the 2009/2010 season had increased by 11.7% in provinces with helmet mandatory and by 17.9% in provinces without helmet mandatory (all p < 0.001), respectively. Helmet use in people older than 15 years was lower in provinces with helmet mandatory compared with provinces without mandatory (63.1% vs. 68.1%, p < 0.001) in the 2009/2010 season.

Conclusion: A helmet mandatory for people aged 15 years or less may increase helmet use in involved age groups when helmet use is relatively low. However, public discussions

and preventive helmet campaigns based on sound theories of health behavior change may also induce increases in helmet use in skiers aged older than 15 years without helmet mandatory.”
“Stemona selleck compound spp. have been traditionally used as natural pesticides and medicinal plants. S. curtisii, a dominant species of south and southwest Thailand, attracted attention for its insecticidal properties caused by specific alkaloids. A HPLC analytical method for quantitative determination of the major derivatives oxystemokerrine, stemocurtisine, stemocurtisinol, and stemofoline in root extracts of S. curtisii was developed. The method was validated for its linearity, precision, accuracy, limit of detection (LOD) and limit of quantitation (LOQ). Ten root samples were collected from various localities in Thailand and investigated for their insecticidal activities against neonate larvae of Spodoptera littoralis. Stemofoline was shown to possess the highest insecticidal activity with a LC50 value at 2.4 ppm and EC50 at 0.98 ppm. The present work provides a simultaneous HPLC analysis for quality assessment and standardization of S. curtisii raw materials, extracts and final products with regard to active Stemona alkaloids for further development as high quality natural insecticidal products. (C) 2012 Elsevier B.V. All rights reserved.

This series was evaluated at minimum of twenty years Twelve pati

This series was evaluated at minimum of twenty years. Twelve patients (fourteen hips) were living at twenty years. In this group of sixty-one arthroplasties,

there were nineteen revisions in fourteen hips (22.9%) during the follow-up period, but no revisions were performed because of loosening of the acetabular component and no additional cups had loosened since the time of the last report at a minimum of ten years. Two components had previously been reported as loose and had migrated, but neither had been revised EPZ5676 clinical trial at the time of the latest follow-up. The minimum twenty-year follow-up of these cementless acetabular components demonstrated durable long-term fixation. The survival rate was 100% with revision of the shell because of aseptic loosening as the end point and 97.7% (95% confidence interval, +/- 8.8%) with radiographic evidence of loosening as the end point. The authors continue INCB028050 datasheet to use cementless acetabular fixation with screw augmentation for most revision total hip arthroplasty procedures.”
“Background: Beyond the first year after a heart transplant (HT) procedure, patients often develop

dyslipidemias, which may be implicated in the genesis of transplant coronary heart disease. High-density lipoprotein (HDL) has a several anti-atherogenic properties, but the status of HDL in HT patients is still controversial. Nonetheless, determination of HDL cholesterol concentration is not sufficient for evaluation of the overall HDL protective role. In this study, a fundamental GSK621 mw functional property of HDL, the ability to simultaneously receive the major lipid classes, was tested in HT patients.

Methods: Twenty HT patients and 20 healthy normolipidemic subjects paired for gender, age and body mass index were studied. Blood samples were collected after 12-hour fasting for determination of plasma lipids, glucose, paraxonase I (PON 1) activity, HDL diameter and transfer of labeled lipids from an artificial nanoemulsion to HDL.

Results: Plasma triglycerides (159 +/- 63 vs 94 +/- 35 mg/dl)

and glucose (104 +/- 20 vs 86 +/- 10 mg/dl) were greater in HT patients than in control subjects. HDL cholesterol was lower and HDL diameter was smaller in the HT group (HDL cholesterol: 44 +/- 11 vs 55 +/- 15 mg/dl; HDL diameter: 8.8 +/- 0.6 vs 9.0 +/- 1.2 nm). PON 1 activity did not differ (87 +/- 47 vs 75 +/- 37 nmol/min/ml). The transfer rates of free cholesterol and cholesteryl esters were diminished in HT patients (HT: 8.4 +/- 1.2% and 3.8 +/- 0.6%; controls: 9.7 +/- 1.9% and 4.7 +/- 1.2%, respectively).

Conclusions: The transfer of free cholesterol and cholesteryl esters to HDL is diminished in HT patients; disturbance in the ability of HDL to receive lipids may affect the anti-atherogenic properties of the lipoprotein. J Heart Lung Transplant 2009;28:1075-80.